Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004014946> ?p ?o ?g. }
- W2004014946 endingPage "147" @default.
- W2004014946 startingPage "137" @default.
- W2004014946 abstract "Lipid nanoparticles (LNP) coated by a poly(oxyethylene) polymer have been manufactured from low cost and human use-approved materials, by an easy, robust, and up-scalable process. The incorporation in the formulation of maleimide-grafted surfactants allows the functionalization of the lipid cargos by targeting ligands such as the cRGD peptide binding to αvβ3 integrin, a well-known angiogenesis biomarker. LNP are able to encapsulate efficiently lipophilic molecules such as a fluorescent dye, allowing their in vivo tracking using fluorescence imaging. In vitro study on HEK293(β3) cells over-expressing the αvβ3 integrins demonstrates the functionalization, specific targeting, and internalization of cRGD-functionalized LNP in comparison with LNP-cRAD or LNP-OH used as negative controls. Following their intravenous injection in Nude mice, LNP-cRGD can accumulate actively in slow-growing HEK293(β3) cancer xenografts, leading to tumor over skin fluorescence ratio of 1.53 ± 0.07 (n = 3) 24 h after injection. In another fast-growing tumor model (TS/A-pc), tumor over skin fluorescence ratio is improved (2.60 ± 0.48, n = 3), but specificity between the different LNP functionalizations is no more observed. The different results obtained for the two tumor models are discussed in terms of active cRGD targeting and/or passive nanoparticle accumulation due to the Enhanced Permeability and Retention effect." @default.
- W2004014946 created "2016-06-24" @default.
- W2004014946 creator A5012515452 @default.
- W2004014946 creator A5013509622 @default.
- W2004014946 creator A5019124813 @default.
- W2004014946 creator A5025350742 @default.
- W2004014946 creator A5032971654 @default.
- W2004014946 creator A5052444841 @default.
- W2004014946 creator A5063801352 @default.
- W2004014946 creator A5072017923 @default.
- W2004014946 creator A5079396522 @default.
- W2004014946 date "2010-06-01" @default.
- W2004014946 modified "2023-10-11" @default.
- W2004014946 title "Tumor targeting of functionalized lipid nanoparticles: Assessment by in vivo fluorescence imaging" @default.
- W2004014946 cites W1205374584 @default.
- W2004014946 cites W1573363574 @default.
- W2004014946 cites W1971145143 @default.
- W2004014946 cites W1972856288 @default.
- W2004014946 cites W1980320853 @default.
- W2004014946 cites W1980797590 @default.
- W2004014946 cites W1981937465 @default.
- W2004014946 cites W1982686059 @default.
- W2004014946 cites W1989195046 @default.
- W2004014946 cites W1992865052 @default.
- W2004014946 cites W1993777198 @default.
- W2004014946 cites W1994766582 @default.
- W2004014946 cites W1995855261 @default.
- W2004014946 cites W1997765535 @default.
- W2004014946 cites W2002516695 @default.
- W2004014946 cites W2005425959 @default.
- W2004014946 cites W2006658714 @default.
- W2004014946 cites W2016156919 @default.
- W2004014946 cites W2017818795 @default.
- W2004014946 cites W2021248540 @default.
- W2004014946 cites W2032760352 @default.
- W2004014946 cites W2040485132 @default.
- W2004014946 cites W2043499815 @default.
- W2004014946 cites W2043904897 @default.
- W2004014946 cites W2044072446 @default.
- W2004014946 cites W2049886572 @default.
- W2004014946 cites W2054189154 @default.
- W2004014946 cites W2061510929 @default.
- W2004014946 cites W2064863505 @default.
- W2004014946 cites W2067314913 @default.
- W2004014946 cites W2082865634 @default.
- W2004014946 cites W2091121756 @default.
- W2004014946 cites W2091907258 @default.
- W2004014946 cites W2097457582 @default.
- W2004014946 cites W2110908521 @default.
- W2004014946 cites W2112687126 @default.
- W2004014946 cites W2119507443 @default.
- W2004014946 cites W2121357123 @default.
- W2004014946 cites W2122426644 @default.
- W2004014946 cites W2133254501 @default.
- W2004014946 cites W2141162588 @default.
- W2004014946 cites W2144714372 @default.
- W2004014946 cites W2145410024 @default.
- W2004014946 cites W2150471474 @default.
- W2004014946 cites W2161222704 @default.
- W2004014946 cites W2163010987 @default.
- W2004014946 cites W2335752216 @default.
- W2004014946 cites W2410964157 @default.
- W2004014946 cites W3018336393 @default.
- W2004014946 cites W4241757664 @default.
- W2004014946 cites W4242601767 @default.
- W2004014946 doi "https://doi.org/10.1016/j.ejpb.2010.02.007" @default.
- W2004014946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20149869" @default.
- W2004014946 hasPublicationYear "2010" @default.
- W2004014946 type Work @default.
- W2004014946 sameAs 2004014946 @default.
- W2004014946 citedByCount "114" @default.
- W2004014946 countsByYear W20040149462012 @default.
- W2004014946 countsByYear W20040149462013 @default.
- W2004014946 countsByYear W20040149462014 @default.
- W2004014946 countsByYear W20040149462015 @default.
- W2004014946 countsByYear W20040149462016 @default.
- W2004014946 countsByYear W20040149462017 @default.
- W2004014946 countsByYear W20040149462018 @default.
- W2004014946 countsByYear W20040149462019 @default.
- W2004014946 countsByYear W20040149462020 @default.
- W2004014946 countsByYear W20040149462021 @default.
- W2004014946 countsByYear W20040149462022 @default.
- W2004014946 countsByYear W20040149462023 @default.
- W2004014946 crossrefType "journal-article" @default.
- W2004014946 hasAuthorship W2004014946A5012515452 @default.
- W2004014946 hasAuthorship W2004014946A5013509622 @default.
- W2004014946 hasAuthorship W2004014946A5019124813 @default.
- W2004014946 hasAuthorship W2004014946A5025350742 @default.
- W2004014946 hasAuthorship W2004014946A5032971654 @default.
- W2004014946 hasAuthorship W2004014946A5052444841 @default.
- W2004014946 hasAuthorship W2004014946A5063801352 @default.
- W2004014946 hasAuthorship W2004014946A5072017923 @default.
- W2004014946 hasAuthorship W2004014946A5079396522 @default.
- W2004014946 hasConcept C115537861 @default.
- W2004014946 hasConcept C121332964 @default.
- W2004014946 hasConcept C12554922 @default.
- W2004014946 hasConcept C139770010 @default.
- W2004014946 hasConcept C147789679 @default.