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- W2004014992 abstract "Electrophoretic studies on microheterogeneity of α2-macroglobulin (α2M) have revealed the presence of an abnormal acidic form of α2M in multiple sclerosis (MS). In the present study we have characterized α2M chemically and compared the inhibitory effect of MS and normal α2M on the mitogen induction of lymphocyte proliferation. The antitrypsin activity and total reducing sugar content of MS α2M were comparable with those of normal α2M. However, the sialic acid content of MS α2M was found to be significantly higher than that of normal α2M. In agreement with previous studies, normal α2M was found to inhibit the mitogen induction of lymphocyte proliferation in more than 90% cell cultures. However, MS α2M was found to inhibit the mitogen-induced lymphocyte proliferation in less than 35 percent cell cultures. The effects of MS or normal α2M on the lymphocyte cultures of either groups were found to be apparently the same. The possible explanations for the loss of the above-mentioned inhibitory effect of MS α2M have been discussed." @default.
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- W2004014992 title "Effect of multiple sclerosis α2-macroglobulin on mitogen induction of lymphocyte proliferation" @default.
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- W2004014992 doi "https://doi.org/10.1016/s0171-2985(85)80015-2" @default.
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