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• W2004020018 abstract "Genetic studies of the enzymes controlling synthesis of pyrimidines in E. coli show that the four loci determining the structure of DHOase,† DHOdehase, OMPppase and OMPdecase are closely linked on the chromosome. The loci controlling the structure of ATCase and of an enzyme concerned with the cell's requirement for carbamyl phosphate are situated at different chromosomal sites and are not linked to the group of four enzymes cited or to each other. Under conditions of repression and derepression, the linked group of four enzymes is controlled coordinately whereas the latter two enzymes vary in a non-coordinate fashion. Pyrimidine analogues may disrupt coordination in the group of four enzymes but this altered behavior appears to result from the non-specific effects of such analogues on protein synthesis." @default.
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• W2004020018 date "1962-12-01" @default.
• W2004020018 modified "2023-10-10" @default.
• W2004020018 title "Coordination of the synthesis of the enzymes in the pyrimidine pathway of E. coli" @default.
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• W2004020018 doi "https://doi.org/10.1016/s0022-2836(62)80090-4" @default.
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