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- W2004022011 abstract "In the present study the effect of thyroid hormone (T3) on oxidative stress parameters of mitochondria of rat liver is reported. Hypothyroidism is induced in male adult rats by giving 0.05% propylthiouracil (PTU) in drinking water for 30 days and in order to know the effect of thyroid hormone, PTU-treated rats were injected with 20 μg T3/100 g body weight/day for 3 days. The results of the present study indicate that administration of T3 to hypothyroid (PTU-treated) rats resulted in significant augmentation of oxidative stress parameters such as thiobarbituric acid reactive substances and protein carbonyl content of mitochondria in comparison to its control and euthyroid rats. The hydrogen peroxide content of the mitochondria of liver increased in hypothyroid rats and was brought to a normal level by T3 treatment. Induction of hypothyroidism by PTU treatment to rats also resulted in the augmentation of total and CN-sensitive superoxide dismutase (SOD) activities of the mitochondria, which was reduced when hypothyroid rats were challenged with T3. Although CN-resistant SOD activity of the mitochondria remained unaltered in response to hypothyroidism induced by PTU treatment, its activity decreased when hypothyroid rats were injected with T3. The catalase activity of the mitochondria decreased significantly by PTU treatment and was restored to normal when PTU-treated rats were given T3. Total, Se-independent and Se-dependent glutathione peroxidase activities of the mitochondria were increased following PTU treatment and reduced when T3 was administered to PTU-treated rats. The reduced and oxidised glutathione contents of the mitochondria of liver increased significantly in hypothyroid rats and their level was restored to normal when hypothyroid rats were injected with T3. The results of the present study suggest that the mitochondrial antioxidant defence system is considerably influenced by the thyroid states of the body." @default.
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- W2004022011 date "2001-07-01" @default.
- W2004022011 modified "2023-09-27" @default.
- W2004022011 title "Modulation of rat liver mitochondrial antioxidant defence system by thyroid hormone" @default.
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- W2004022011 doi "https://doi.org/10.1016/s0925-4439(01)00048-5" @default.
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