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- W2004023718 abstract "1. Endothelium-derived hyperpolarization (EDH) has been reported in many vessels and an extensive literature suggests that a novel, non-nitric oxide and non-prostanoid, endothelium-derived factor(s) may be synthesized in endothelial cells. 2. The endothelium-dependent hyperpolarizing factor, or EDHF, is synthesized by the putative EDHF synthase and mediates its cellular effects by either, directly or indirectly, opening K channels on vascular smooth muscle cells or, via hyperpolarization of the endothelial cell, by facilitating electrical coupling between the endothelial and the vascular smooth muscle cell. 3. The question of the chemical identity of EDHF has received considerable attention; however, no consensus has been reached. Tissue and species heterogeneity exists that may imply there are multiple EDHF. Leading candidate molecules for EDHF include an arachidonic acid product, possibly an epoxygenase product, or an endogenous cannabinoid, or simply an increase in extracellular K+. 4. An increasing body of evidence suggests that EDH, notably in the resistance vasculature, may be mediated via electrical coupling through myoendothelial gap junctions and the existence of electrical coupling may negate the need to hypothesize the existence of a true endothelium-derived chemical mediator. 5. In this paper we review the evidence that supports and refutes the existence of a novel EDHF versus a hyperpolarization event mediated solely by myoendothelial gap junctions." @default.
- W2004023718 created "2016-06-24" @default.
- W2004023718 creator A5027044037 @default.
- W2004023718 creator A5084792115 @default.
- W2004023718 date "2002-03-01" @default.
- W2004023718 modified "2023-10-14" @default.
- W2004023718 title "Endothelium-Derived Hyperpolarizing Factor: Is There A Novel Chemical Mediator?" @default.
- W2004023718 cites W111614627 @default.
- W2004023718 cites W1540295714 @default.
- W2004023718 cites W1546802604 @default.
- W2004023718 cites W1550864250 @default.
- W2004023718 cites W1619653867 @default.
- W2004023718 cites W1753089048 @default.
- W2004023718 cites W178888420 @default.
- W2004023718 cites W1936822231 @default.
- W2004023718 cites W1957610597 @default.
- W2004023718 cites W1964534899 @default.
- W2004023718 cites W1965362276 @default.
- W2004023718 cites W1968402657 @default.
- W2004023718 cites W1969453374 @default.
- W2004023718 cites W1972766090 @default.
- W2004023718 cites W1979017186 @default.
- W2004023718 cites W1982993995 @default.
- W2004023718 cites W1983699989 @default.
- W2004023718 cites W1988737490 @default.
- W2004023718 cites W1993404169 @default.
- W2004023718 cites W1996394751 @default.
- W2004023718 cites W1997557173 @default.
- W2004023718 cites W2005284425 @default.
- W2004023718 cites W2007358788 @default.
- W2004023718 cites W2007820026 @default.
- W2004023718 cites W2012833873 @default.
- W2004023718 cites W2015305787 @default.
- W2004023718 cites W2021724833 @default.
- W2004023718 cites W2021783313 @default.
- W2004023718 cites W2027662236 @default.
- W2004023718 cites W2030468978 @default.
- W2004023718 cites W2038021990 @default.
- W2004023718 cites W2041899253 @default.
- W2004023718 cites W2044130743 @default.
- W2004023718 cites W2044930326 @default.
- W2004023718 cites W2045550377 @default.
- W2004023718 cites W2047715774 @default.
- W2004023718 cites W2051059634 @default.
- W2004023718 cites W2053863364 @default.
- W2004023718 cites W2056873485 @default.
- W2004023718 cites W2063503589 @default.
- W2004023718 cites W2066263460 @default.
- W2004023718 cites W2067206788 @default.
- W2004023718 cites W2069035576 @default.
- W2004023718 cites W2071969879 @default.
- W2004023718 cites W2074410830 @default.
- W2004023718 cites W2076783344 @default.
- W2004023718 cites W2079955127 @default.
- W2004023718 cites W2082988280 @default.
- W2004023718 cites W2084691167 @default.
- W2004023718 cites W2085367013 @default.
- W2004023718 cites W2090888808 @default.
- W2004023718 cites W2090968114 @default.
- W2004023718 cites W2091193879 @default.
- W2004023718 cites W2105864994 @default.
- W2004023718 cites W2109893227 @default.
- W2004023718 cites W2112588391 @default.
- W2004023718 cites W2113722141 @default.
- W2004023718 cites W2118644794 @default.
- W2004023718 cites W2119350257 @default.
- W2004023718 cites W2122861141 @default.
- W2004023718 cites W2125657777 @default.
- W2004023718 cites W2126029591 @default.
- W2004023718 cites W2126811481 @default.
- W2004023718 cites W2128738543 @default.
- W2004023718 cites W2129522937 @default.
- W2004023718 cites W2134397441 @default.
- W2004023718 cites W2138046394 @default.
- W2004023718 cites W2139460549 @default.
- W2004023718 cites W2144486173 @default.
- W2004023718 cites W2150066361 @default.
- W2004023718 cites W2154063166 @default.
- W2004023718 cites W2160193184 @default.
- W2004023718 cites W2162439295 @default.
- W2004023718 cites W2168823348 @default.
- W2004023718 cites W2169182236 @default.
- W2004023718 cites W2183123602 @default.
- W2004023718 cites W2298372757 @default.
- W2004023718 cites W2395707267 @default.
- W2004023718 cites W4232089540 @default.
- W2004023718 cites W4234986182 @default.
- W2004023718 cites W4237301381 @default.
- W2004023718 cites W4362110548 @default.
- W2004023718 cites W61150337 @default.
- W2004023718 doi "https://doi.org/10.1046/j.1440-1681.2002.03632.x" @default.
- W2004023718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11906476" @default.
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