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- W2004027863 abstract "A brain-derived neurotrophic factor (BDNF) receptor TrkB involves three spliced variants, namely the tyrosine kinase domain (TK) intact (+) and two TK(−) isoforms T1 and T2, yet their precise roles are largely unknown. Here we extensively map the mRNA expression patterns of BDNF and TrkB variants, further to gain insights in TK(−) specific functions during mouse development. Consequently, we found that TK(+), T1 and T2 were expressed in distinct regions of the mouse nervous system at the embryonic and postnatal stages, implicating separable functions of TK(−) forms. Additionally we uncovered five expressed segments in the intron between T2 and T1 specific exons, and one of these segments was revealed to code novel TK(−) receptors with unique responsiveness in vitro. These results suggest dynamic modes of expression from the Ntrk2 gene locus and multiple roles of TK(−) forms in the developing mouse nervous system." @default.
- W2004027863 created "2016-06-24" @default.
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- W2004027863 date "2008-10-01" @default.
- W2004027863 modified "2023-09-27" @default.
- W2004027863 title "Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system" @default.
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- W2004027863 doi "https://doi.org/10.1016/j.mcn.2008.07.024" @default.
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