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• W2004030786 abstract "The complexes [Pd(valp)2(imidazole)2] (1), [Pd(valp)2(pyrazine)2] (2) (valp is sodium valproate) have been synthesized and characterized using IR, 1H NMR, 13C{1H} NMR and UV–Vis spectrometry. The interaction of complexes with CT-DNA has been investigated using spectroscopic tools and viscosity measurement. In each case, the association constant (Kb) was deduced from the absorption spectral study and the number of binding sites (n) and the binding constant (K) were calculated from relevant fluorescence quenching data. As a result, a non-covalent interaction between the metal complex and DNA was suggested, which could be assigned to an intercalative binding. In addition, the interaction of 1 and 2 was ventured with bovine serum albumin (BSA) with the help of absorption and fluorescence spectroscopy measurements. Through these techniques, the apparent association constant (Kapp) and the binding constant (K) could be calculated for each complex. Evaluation of cytotoxic activity of the complexes against four different cancer cell lines proved that the complexes exhibited cytotoxic specificity and significant cancer cell inhibitory rate. Moreover, density functional theory (DFT) calculations were employed to provide more evidence about the observed data. The majority of trans isomers were supported not only by energies, but also by the similarity of its calculated IR frequencies, UV adsorptions and NMR chemical shifts to the experimental values." @default.
• W2004030786 created "2016-06-24" @default.
• W2004030786 creator A5020153911 @default.
• W2004030786 creator A5024898128 @default.
• W2004030786 creator A5033060269 @default.
• W2004030786 date "2015-04-01" @default.
• W2004030786 modified "2023-09-25" @default.
• W2004030786 title "New mixed ligand palladium(II) complexes based on the antiepileptic drug sodium valproate and bioactive nitrogen-donor ligands: Synthesis, structural characterization, binding interactions with DNA and BSA, in vitro cytotoxicity studies and DFT calculations" @default.
• W2004030786 cites W132100242 @default.
• W2004030786 cites W1523096735 @default.
• W2004030786 cites W1965169564 @default.
• W2004030786 cites W1966545431 @default.
• W2004030786 cites W1971920947 @default.
• W2004030786 cites W1974693247 @default.
• W2004030786 cites W1975402304 @default.
• W2004030786 cites W1978848032 @default.
• W2004030786 cites W1979512796 @default.
• W2004030786 cites W1982123637 @default.
• W2004030786 cites W1984783825 @default.
• W2004030786 cites W1986633321 @default.
• W2004030786 cites W1988007606 @default.
• W2004030786 cites W1990901889 @default.
• W2004030786 cites W1993383767 @default.
• W2004030786 cites W1993584747 @default.
• W2004030786 cites W1995945130 @default.
• W2004030786 cites W1996318087 @default.
• W2004030786 cites W1997054462 @default.
• W2004030786 cites W1999153581 @default.
• W2004030786 cites W2000774559 @default.
• W2004030786 cites W2001813159 @default.
• W2004030786 cites W2003138430 @default.
• W2004030786 cites W2004208374 @default.
• W2004030786 cites W2004793512 @default.
• W2004030786 cites W2007958204 @default.
• W2004030786 cites W2013357973 @default.
• W2004030786 cites W2023271753 @default.
• W2004030786 cites W2030843464 @default.
• W2004030786 cites W2031117956 @default.
• W2004030786 cites W2032058801 @default.
• W2004030786 cites W2033532170 @default.
• W2004030786 cites W2036584559 @default.
• W2004030786 cites W2038767330 @default.
• W2004030786 cites W2038822441 @default.
• W2004030786 cites W2039991020 @default.
• W2004030786 cites W2040322379 @default.
• W2004030786 cites W2040480930 @default.
• W2004030786 cites W2041854369 @default.
• W2004030786 cites W2042062103 @default.
• W2004030786 cites W2042313778 @default.
• W2004030786 cites W2044921763 @default.
• W2004030786 cites W2046057219 @default.
• W2004030786 cites W2049907729 @default.
• W2004030786 cites W2049996223 @default.
• W2004030786 cites W2050806558 @default.
• W2004030786 cites W2051314621 @default.
• W2004030786 cites W2052736304 @default.
• W2004030786 cites W2053535968 @default.
• W2004030786 cites W2055929104 @default.
• W2004030786 cites W2057436992 @default.
• W2004030786 cites W2058398316 @default.
• W2004030786 cites W2060486166 @default.
• W2004030786 cites W2061061788 @default.
• W2004030786 cites W2063663126 @default.
• W2004030786 cites W2064539724 @default.
• W2004030786 cites W2067237008 @default.
• W2004030786 cites W2068256510 @default.
• W2004030786 cites W2069197437 @default.
• W2004030786 cites W2071846164 @default.
• W2004030786 cites W2073356400 @default.
• W2004030786 cites W2074505041 @default.
• W2004030786 cites W2074635589 @default.
• W2004030786 cites W2078020979 @default.
• W2004030786 cites W2078821865 @default.
• W2004030786 cites W2078964194 @default.
• W2004030786 cites W2086382728 @default.
• W2004030786 cites W2093271466 @default.
• W2004030786 cites W2095361625 @default.
• W2004030786 cites W2108077209 @default.
• W2004030786 cites W2124559446 @default.
• W2004030786 cites W2143981217 @default.
• W2004030786 cites W2146133266 @default.
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• W2004030786 cites W2157633570 @default.
• W2004030786 cites W2466734896 @default.
• W2004030786 cites W2522614588 @default.
• W2004030786 cites W271256994 @default.
• W2004030786 cites W2949691136 @default.
• W2004030786 cites W327629993 @default.
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• W2004030786 doi "https://doi.org/10.1016/j.saa.2015.01.027" @default.
• W2004030786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25659738" @default.
• W2004030786 hasPublicationYear "2015" @default.
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