Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004031736> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2004031736 endingPage "351" @default.
- W2004031736 startingPage "341" @default.
- W2004031736 abstract "SUMMARY Graded doses of propylthiouracil, carbimazole, sulphadiazine, potassium perchlorate and potassium thiocyanate were fed to groups of rats under standardized conditions for 2 months. The rats were given 131 I 24 hr. before they were killed, and the thyroid weight, the proportions of labelled iodoaminoacids, and the thyroidal iodine content were determined. All the goitrogens produced increase in thyroid size, reduction of thyroidal iodine content, and an elevation of the monoiodotyrosine: di-iodotyrosine (MIT:DIT) ratio. The tri-iodothyronine: thyroxine (T 3 : T 4 ) ratio was usually increased. Irrespective of the antithyroid compound used, there was a close correlation between the decrease in thyroidal iodine content and the rise in the MIT:DIT ratio. In further experiments, either thyroid stimulating hormone (TSH) or thyroxine were injected s.c. twice daily for 5 days. TSH decreased the MIT:DIT ratio and increased the amount of labelled T 3 . Thyroxine increased the MIT:DIT ratio and decreased the amount of T 4 . It is suggested that when goitrogens were administered for a prolonged period, the pattern of 131 I-labelling of iodoaminoacids was dependent on a balance between inhibition of synthesis caused by the goitrogen and stimulation due to TSH. There was increased production of the physiologically more economical T 3 in an attempt to compensate for decreased thyroxine formation." @default.
- W2004031736 created "2016-06-24" @default.
- W2004031736 creator A5022332050 @default.
- W2004031736 creator A5050407368 @default.
- W2004031736 creator A5079359285 @default.
- W2004031736 date "1965-07-01" @default.
- W2004031736 modified "2023-10-18" @default.
- W2004031736 title "THE EFFECT OF PROLONGED FEEDING OF GOITROGENS ON THYROID FUNCTION IN RATS" @default.
- W2004031736 doi "https://doi.org/10.1677/joe.0.0320341" @default.
- W2004031736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14322056" @default.
- W2004031736 hasPublicationYear "1965" @default.
- W2004031736 type Work @default.
- W2004031736 sameAs 2004031736 @default.
- W2004031736 citedByCount "7" @default.
- W2004031736 countsByYear W20040317362022 @default.
- W2004031736 crossrefType "journal-article" @default.
- W2004031736 hasAuthorship W2004031736A5022332050 @default.
- W2004031736 hasAuthorship W2004031736A5050407368 @default.
- W2004031736 hasAuthorship W2004031736A5079359285 @default.
- W2004031736 hasConcept C126322002 @default.
- W2004031736 hasConcept C134018914 @default.
- W2004031736 hasConcept C158479217 @default.
- W2004031736 hasConcept C178790620 @default.
- W2004031736 hasConcept C179104552 @default.
- W2004031736 hasConcept C185592680 @default.
- W2004031736 hasConcept C2775960720 @default.
- W2004031736 hasConcept C2778288131 @default.
- W2004031736 hasConcept C2778417266 @default.
- W2004031736 hasConcept C2781182303 @default.
- W2004031736 hasConcept C2993291352 @default.
- W2004031736 hasConcept C526584372 @default.
- W2004031736 hasConcept C539932907 @default.
- W2004031736 hasConcept C71315377 @default.
- W2004031736 hasConcept C71924100 @default.
- W2004031736 hasConceptScore W2004031736C126322002 @default.
- W2004031736 hasConceptScore W2004031736C134018914 @default.
- W2004031736 hasConceptScore W2004031736C158479217 @default.
- W2004031736 hasConceptScore W2004031736C178790620 @default.
- W2004031736 hasConceptScore W2004031736C179104552 @default.
- W2004031736 hasConceptScore W2004031736C185592680 @default.
- W2004031736 hasConceptScore W2004031736C2775960720 @default.
- W2004031736 hasConceptScore W2004031736C2778288131 @default.
- W2004031736 hasConceptScore W2004031736C2778417266 @default.
- W2004031736 hasConceptScore W2004031736C2781182303 @default.
- W2004031736 hasConceptScore W2004031736C2993291352 @default.
- W2004031736 hasConceptScore W2004031736C526584372 @default.
- W2004031736 hasConceptScore W2004031736C539932907 @default.
- W2004031736 hasConceptScore W2004031736C71315377 @default.
- W2004031736 hasConceptScore W2004031736C71924100 @default.
- W2004031736 hasIssue "3" @default.
- W2004031736 hasLocation W20040317361 @default.
- W2004031736 hasLocation W20040317362 @default.
- W2004031736 hasOpenAccess W2004031736 @default.
- W2004031736 hasPrimaryLocation W20040317361 @default.
- W2004031736 hasRelatedWork W1977833798 @default.
- W2004031736 hasRelatedWork W1980329853 @default.
- W2004031736 hasRelatedWork W2004031736 @default.
- W2004031736 hasRelatedWork W2041370700 @default.
- W2004031736 hasRelatedWork W2050375916 @default.
- W2004031736 hasRelatedWork W2055124061 @default.
- W2004031736 hasRelatedWork W2075256037 @default.
- W2004031736 hasRelatedWork W2120821732 @default.
- W2004031736 hasRelatedWork W2155312245 @default.
- W2004031736 hasRelatedWork W2355082016 @default.
- W2004031736 hasVolume "32" @default.
- W2004031736 isParatext "false" @default.
- W2004031736 isRetracted "false" @default.
- W2004031736 magId "2004031736" @default.
- W2004031736 workType "article" @default.