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- W2004037499 abstract "Naturally occurring substances were of inestimable value to the founding fathers of modern pharmacology in their early studies into the nature and properties of neurotransmitter receptors. Even today, chemical substances derived from the animal and plant kingdom are of crucial importance to biochemical pharmacologists studying the mechanisms by which hormonal signals are communicated from the cell surface to the intracellular compartment. Signal transduction is a complex procedure which involves the linkage of a receptor, via a coupling protein (usually a guanine nucleotide binding protein or G-protein), to a system which produces second messengers (adenylate cyclase, phosphoinositidase C or an ion channel) or directly to an ion channel. Not only has nature provided a variety of agents that can mimic or antagonize the actions of hormones at the cell surface, but it has also provided a wealth of substances that can modify the signal transduction process at a post receptor level. In this article, we discuss the sources and the mechanisms of action of a selection of the most widely used of these latter agents and show how they have helped the modern biochemical pharmacologist to gain an insight into the fundamental mechanisms involved in signal transduction." @default.
- W2004037499 created "2016-06-24" @default.
- W2004037499 creator A5033703663 @default.
- W2004037499 creator A5078932686 @default.
- W2004037499 date "1987-03-01" @default.
- W2004037499 modified "2023-09-26" @default.
- W2004037499 title "The interaction of natural products with cellular signalling mechanisms" @default.
- W2004037499 cites W1015369645 @default.
- W2004037499 cites W1483833346 @default.
- W2004037499 cites W1483853294 @default.
- W2004037499 cites W1485278468 @default.
- W2004037499 cites W1485683585 @default.
- W2004037499 cites W1486896527 @default.
- W2004037499 cites W1494647602 @default.
- W2004037499 cites W1496864275 @default.
- W2004037499 cites W1500700435 @default.
- W2004037499 cites W1507560840 @default.
- W2004037499 cites W1511887721 @default.
- W2004037499 cites W1515479627 @default.
- W2004037499 cites W1520699482 @default.
- W2004037499 cites W1532747508 @default.
- W2004037499 cites W1533101741 @default.
- W2004037499 cites W1539001739 @default.
- W2004037499 cites W1539182280 @default.
- W2004037499 cites W1544390306 @default.
- W2004037499 cites W1557145999 @default.
- W2004037499 cites W1561980328 @default.
- W2004037499 cites W1568167591 @default.
- W2004037499 cites W1577883243 @default.
- W2004037499 cites W1589866689 @default.
- W2004037499 cites W1595160908 @default.
- W2004037499 cites W1597332117 @default.
- W2004037499 cites W1600624424 @default.
- W2004037499 cites W1649341288 @default.
- W2004037499 cites W1887017620 @default.
- W2004037499 cites W1963941498 @default.
- W2004037499 cites W1964839077 @default.
- W2004037499 cites W1965531456 @default.
- W2004037499 cites W1969755572 @default.
- W2004037499 cites W1971533328 @default.
- W2004037499 cites W1973123618 @default.
- W2004037499 cites W1975361019 @default.
- W2004037499 cites W1975530116 @default.
- W2004037499 cites W1978274173 @default.
- W2004037499 cites W1980854090 @default.
- W2004037499 cites W1981018920 @default.
- W2004037499 cites W1981880855 @default.
- W2004037499 cites W1982594839 @default.
- W2004037499 cites W1982960066 @default.
- W2004037499 cites W1983959862 @default.
- W2004037499 cites W1985134826 @default.
- W2004037499 cites W1990369193 @default.
- W2004037499 cites W1992383744 @default.
- W2004037499 cites W1998408802 @default.
- W2004037499 cites W2000523761 @default.
- W2004037499 cites W2001133545 @default.
- W2004037499 cites W2001201602 @default.
- W2004037499 cites W2001692359 @default.
- W2004037499 cites W2002500227 @default.
- W2004037499 cites W2009064952 @default.
- W2004037499 cites W2009291798 @default.
- W2004037499 cites W2010820226 @default.
- W2004037499 cites W2011976654 @default.
- W2004037499 cites W2020137064 @default.
- W2004037499 cites W2020629288 @default.
- W2004037499 cites W2026900028 @default.
- W2004037499 cites W2027704731 @default.
- W2004037499 cites W2030834479 @default.
- W2004037499 cites W2031306886 @default.
- W2004037499 cites W2037867344 @default.
- W2004037499 cites W2038542572 @default.
- W2004037499 cites W2038993552 @default.
- W2004037499 cites W2039592913 @default.
- W2004037499 cites W2040757157 @default.
- W2004037499 cites W2043390449 @default.
- W2004037499 cites W2043498158 @default.
- W2004037499 cites W2047458497 @default.
- W2004037499 cites W2051033060 @default.
- W2004037499 cites W2051505191 @default.
- W2004037499 cites W2052673887 @default.
- W2004037499 cites W2053507907 @default.
- W2004037499 cites W2056074494 @default.
- W2004037499 cites W2060497494 @default.
- W2004037499 cites W2061056399 @default.
- W2004037499 cites W2064998787 @default.
- W2004037499 cites W2065224079 @default.
- W2004037499 cites W2066787103 @default.
- W2004037499 cites W2068632644 @default.
- W2004037499 cites W2068877244 @default.
- W2004037499 cites W2069501076 @default.
- W2004037499 cites W2069827661 @default.
- W2004037499 cites W2070904206 @default.
- W2004037499 cites W2071032007 @default.
- W2004037499 cites W2071495883 @default.
- W2004037499 cites W2071577950 @default.
- W2004037499 cites W2072099683 @default.
- W2004037499 cites W2072414415 @default.
- W2004037499 cites W2073733217 @default.