FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004037624> ?p ?o ?g. }

• W2004037624 endingPage "19" @default.
• W2004037624 startingPage "7" @default.
• W2004037624 abstract "Corticosteroids form the basis of treatment in many inflammatory rheumatic diseases, both as systemic treatment and as treatment with local injections to reduce inflammation. In 1948 the first systemic treatment of a patient with a rheumatic disease was given to a woman with severe rheumatoid arthritis (RA); the impressive effect in this patient, and in another 15 patients, was reported by Dr Hench and co-workers in 1949. Systemic corticosteroid treatment was rapidly adopted and used not only for patients with RA but also for those with other rheumatic diseases such as systemic lupus erythematosus—as well as other disorders such as asthma—with a similar positive effect. In the following year, 1950, the Nobel Prize was awarded for the discovery of the structure and biological effects of the adrenal cortex hormones. This open trial was followed by several controlled trials conducted in the UK in which the effects of cortisone were compared with the effects of aspirin in patients with RA—interestingly, without any significant clinical benefit for the cortisone-treated patients. It was not until 1959, in yet another multi-centre trial in Britain, that a significant effect on functional capacity and general well-being was reported after 2 years of treatment with prednisolone, compared to aspirin, in patients with early RA. Despite the dramatic effects that were observed in the severely ill RA patients reported by Hench and co-workers it took 10 years to demonstrate that this effect was superior to the effect of aspirin when the two compounds were compared in controlled trials. Why was this so? One explanation could be in the study designs and the different outcome measures used in the various studies. Perhaps the results in the first comparative studies would have been different if individual response criteria had been used. This is discussed in this chapter." @default.
• W2004037624 created "2016-06-24" @default.
• W2004037624 creator A5002987277 @default.
• W2004037624 creator A5011002229 @default.
• W2004037624 creator A5066051506 @default.
• W2004037624 creator A5082575419 @default.
• W2004037624 date "2004-02-01" @default.
• W2004037624 modified "2023-10-02" @default.
• W2004037624 title "Corticosteroids—from an idea to clinical use" @default.
• W2004037624 cites W1489838244 @default.
• W2004037624 cites W1950393708 @default.
• W2004037624 cites W1972115803 @default.
• W2004037624 cites W1978673047 @default.
• W2004037624 cites W1984505943 @default.
• W2004037624 cites W1993909312 @default.
• W2004037624 cites W1994443194 @default.
• W2004037624 cites W2007400720 @default.
• W2004037624 cites W2007873212 @default.
• W2004037624 cites W2033140213 @default.
• W2004037624 cites W2038364067 @default.
• W2004037624 cites W2062325906 @default.
• W2004037624 cites W2063022713 @default.
• W2004037624 cites W2078979823 @default.
• W2004037624 cites W2086717846 @default.
• W2004037624 cites W2092699833 @default.
• W2004037624 cites W2097048496 @default.
• W2004037624 cites W2121907769 @default.
• W2004037624 cites W2144342665 @default.
• W2004037624 cites W2172241052 @default.
• W2004037624 cites W2412721366 @default.
• W2004037624 cites W2438871080 @default.
• W2004037624 cites W4236343520 @default.
• W2004037624 cites W4251443774 @default.
• W2004037624 doi "https://doi.org/10.1016/j.berh.2003.10.003" @default.
• W2004037624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15123034" @default.
• W2004037624 hasPublicationYear "2004" @default.
• W2004037624 type Work @default.
• W2004037624 sameAs 2004037624 @default.
• W2004037624 citedByCount "34" @default.
• W2004037624 countsByYear W20040376242012 @default.
• W2004037624 countsByYear W20040376242013 @default.
• W2004037624 countsByYear W20040376242014 @default.
• W2004037624 countsByYear W20040376242015 @default.
• W2004037624 countsByYear W20040376242017 @default.
• W2004037624 countsByYear W20040376242018 @default.
• W2004037624 countsByYear W20040376242019 @default.
• W2004037624 countsByYear W20040376242022 @default.
• W2004037624 crossrefType "journal-article" @default.
• W2004037624 hasAuthorship W2004037624A5002987277 @default.
• W2004037624 hasAuthorship W2004037624A5011002229 @default.
• W2004037624 hasAuthorship W2004037624A5066051506 @default.
• W2004037624 hasAuthorship W2004037624A5082575419 @default.
• W2004037624 hasConcept C126322002 @default.
• W2004037624 hasConcept C2776042228 @default.
• W2004037624 hasConcept C2776715498 @default.
• W2004037624 hasConcept C2776804153 @default.
• W2004037624 hasConcept C2777077863 @default.
• W2004037624 hasConcept C2777575956 @default.
• W2004037624 hasConcept C2777628954 @default.
• W2004037624 hasConcept C2777977426 @default.
• W2004037624 hasConcept C2779134260 @default.
• W2004037624 hasConcept C2780484280 @default.
• W2004037624 hasConcept C2908564923 @default.
• W2004037624 hasConcept C2909063479 @default.
• W2004037624 hasConcept C3019758011 @default.
• W2004037624 hasConcept C535046627 @default.
• W2004037624 hasConcept C71924100 @default.
• W2004037624 hasConceptScore W2004037624C126322002 @default.
• W2004037624 hasConceptScore W2004037624C2776042228 @default.
• W2004037624 hasConceptScore W2004037624C2776715498 @default.
• W2004037624 hasConceptScore W2004037624C2776804153 @default.
• W2004037624 hasConceptScore W2004037624C2777077863 @default.
• W2004037624 hasConceptScore W2004037624C2777575956 @default.
• W2004037624 hasConceptScore W2004037624C2777628954 @default.
• W2004037624 hasConceptScore W2004037624C2777977426 @default.
• W2004037624 hasConceptScore W2004037624C2779134260 @default.
• W2004037624 hasConceptScore W2004037624C2780484280 @default.
• W2004037624 hasConceptScore W2004037624C2908564923 @default.
• W2004037624 hasConceptScore W2004037624C2909063479 @default.
• W2004037624 hasConceptScore W2004037624C3019758011 @default.
• W2004037624 hasConceptScore W2004037624C535046627 @default.
• W2004037624 hasConceptScore W2004037624C71924100 @default.
• W2004037624 hasIssue "1" @default.
• W2004037624 hasLocation W20040376241 @default.
• W2004037624 hasLocation W20040376242 @default.
• W2004037624 hasOpenAccess W2004037624 @default.
• W2004037624 hasPrimaryLocation W20040376241 @default.
• W2004037624 hasRelatedWork W1594217602 @default.
• W2004037624 hasRelatedWork W1998183922 @default.
• W2004037624 hasRelatedWork W2042158030 @default.
• W2004037624 hasRelatedWork W2054132526 @default.
• W2004037624 hasRelatedWork W2055857629 @default.
• W2004037624 hasRelatedWork W2409075306 @default.
• W2004037624 hasRelatedWork W2411955762 @default.
• W2004037624 hasRelatedWork W2472924779 @default.
• W2004037624 hasRelatedWork W4234468548 @default.
• W2004037624 hasRelatedWork W4315754225 @default.
• W2004037624 hasVolume "18" @default.

• next