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• W2004039797 abstract "Pharmacogenetics was born within the field of anesthesiology in the mid-1950s with the first observations that genetic factors might affect the response to various pharmacological agents. The first article published in this domain reported on cases of prolonged postoperative muscle relaxation following the administration of succinylcholine due to an inherited variation of drug metabolism involving the enzyme butyrylcholinesterase. [1] Kalow W. Gunn D.R. The relation between dose of succinylcholine and duration of apnea in man. J Pharmacol Exp Ther. 1957; 120: 203-214 PubMed Google Scholar Over this last decade, there has been an explosion of scientific publications in the field of pharmacogenetics, the study of the variability in drug response due to genetic variability. Both pharmacogenetics and pharmacogenomics are used synonymously, but the concept of pharmacogenomics incorporates sophisticated genomic tests and a genome-wide approach to define the inherited nature of drug response." @default.
• W2004039797 created "2016-06-24" @default.
• W2004039797 creator A5003915973 @default.
• W2004039797 date "2005-10-01" @default.
• W2004039797 modified "2023-09-24" @default.
• W2004039797 title "Pharmacogenetics: implications for obstetric anesthesia" @default.
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• W2004039797 doi "https://doi.org/10.1016/j.ijoa.2005.03.005" @default.
• W2004039797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16143506" @default.
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