Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004048256> ?p ?o ?g. }
- W2004048256 endingPage "1196" @default.
- W2004048256 startingPage "1183" @default.
- W2004048256 abstract "An electrophysiology-based forward genetic screen has identified two genes, pickpocket11 (ppk11) and pickpocket16 (ppk16), as being necessary for the homeostatic modulation of presynaptic neurotransmitter release at the Drosophila neuromuscular junction (NMJ). Pickpocket genes encode Degenerin/Epithelial Sodium channel subunits (DEG/ENaC). We demonstrate that ppk11 and ppk16 are necessary in presynaptic motoneurons for both the acute induction and long-term maintenance of synaptic homeostasis. We show that ppk11 and ppk16 are cotranscribed as a single mRNA that is upregulated during homeostatic plasticity. Acute pharmacological inhibition of a PPK11- and PPK16-containing channel abolishes the expression of short- and long-term homeostatic plasticity without altering baseline presynaptic neurotransmitter release, indicating remarkable specificity for homeostatic plasticity rather than NMJ development. Finally, presynaptic calcium imaging experiments support a model in which a PPK11- and PPK16-containing DEG/ENaC channel modulates presynaptic membrane voltage and, thereby, controls calcium channel activity to homeostatically regulate neurotransmitter release." @default.
- W2004048256 created "2016-06-24" @default.
- W2004048256 creator A5000150124 @default.
- W2004048256 creator A5006728364 @default.
- W2004048256 creator A5016265229 @default.
- W2004048256 creator A5045266387 @default.
- W2004048256 creator A5090585459 @default.
- W2004048256 date "2013-09-01" @default.
- W2004048256 modified "2023-10-12" @default.
- W2004048256 title "A Presynaptic ENaC Channel Drives Homeostatic Plasticity" @default.
- W2004048256 cites W1565618263 @default.
- W2004048256 cites W1614445885 @default.
- W2004048256 cites W1642181682 @default.
- W2004048256 cites W1955231649 @default.
- W2004048256 cites W1964049915 @default.
- W2004048256 cites W1971207325 @default.
- W2004048256 cites W1973427588 @default.
- W2004048256 cites W1974642350 @default.
- W2004048256 cites W1979957972 @default.
- W2004048256 cites W1983326785 @default.
- W2004048256 cites W1983763554 @default.
- W2004048256 cites W1984039300 @default.
- W2004048256 cites W1985024877 @default.
- W2004048256 cites W1990711883 @default.
- W2004048256 cites W1991705866 @default.
- W2004048256 cites W1996129013 @default.
- W2004048256 cites W1997955557 @default.
- W2004048256 cites W1999664781 @default.
- W2004048256 cites W2003974913 @default.
- W2004048256 cites W2004873650 @default.
- W2004048256 cites W2005800358 @default.
- W2004048256 cites W2006805865 @default.
- W2004048256 cites W2010997544 @default.
- W2004048256 cites W2013711061 @default.
- W2004048256 cites W2019813402 @default.
- W2004048256 cites W2020449445 @default.
- W2004048256 cites W2022128427 @default.
- W2004048256 cites W2023693875 @default.
- W2004048256 cites W2027829143 @default.
- W2004048256 cites W2028620081 @default.
- W2004048256 cites W2037082175 @default.
- W2004048256 cites W2044614617 @default.
- W2004048256 cites W2047535883 @default.
- W2004048256 cites W2053050328 @default.
- W2004048256 cites W2059668389 @default.
- W2004048256 cites W2062607365 @default.
- W2004048256 cites W2063536600 @default.
- W2004048256 cites W2064396596 @default.
- W2004048256 cites W2065178022 @default.
- W2004048256 cites W2069650500 @default.
- W2004048256 cites W2073440759 @default.
- W2004048256 cites W2075856434 @default.
- W2004048256 cites W2082443574 @default.
- W2004048256 cites W2084725128 @default.
- W2004048256 cites W2085431744 @default.
- W2004048256 cites W2087519172 @default.
- W2004048256 cites W2093174559 @default.
- W2004048256 cites W2094930349 @default.
- W2004048256 cites W2096824423 @default.
- W2004048256 cites W2098190806 @default.
- W2004048256 cites W2108462650 @default.
- W2004048256 cites W2109870708 @default.
- W2004048256 cites W2110402020 @default.
- W2004048256 cites W2112923895 @default.
- W2004048256 cites W2120245762 @default.
- W2004048256 cites W2124595526 @default.
- W2004048256 cites W2141851583 @default.
- W2004048256 cites W2145527534 @default.
- W2004048256 cites W2145791439 @default.
- W2004048256 cites W2159220779 @default.
- W2004048256 cites W2164155027 @default.
- W2004048256 cites W2168028420 @default.
- W2004048256 cites W2171359726 @default.
- W2004048256 cites W2234822783 @default.
- W2004048256 cites W4211264697 @default.
- W2004048256 doi "https://doi.org/10.1016/j.neuron.2013.06.048" @default.
- W2004048256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3784986" @default.
- W2004048256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23973209" @default.
- W2004048256 hasPublicationYear "2013" @default.
- W2004048256 type Work @default.
- W2004048256 sameAs 2004048256 @default.
- W2004048256 citedByCount "91" @default.
- W2004048256 countsByYear W20040482562013 @default.
- W2004048256 countsByYear W20040482562014 @default.
- W2004048256 countsByYear W20040482562015 @default.
- W2004048256 countsByYear W20040482562016 @default.
- W2004048256 countsByYear W20040482562017 @default.
- W2004048256 countsByYear W20040482562018 @default.
- W2004048256 countsByYear W20040482562019 @default.
- W2004048256 countsByYear W20040482562020 @default.
- W2004048256 countsByYear W20040482562021 @default.
- W2004048256 countsByYear W20040482562022 @default.
- W2004048256 countsByYear W20040482562023 @default.
- W2004048256 crossrefType "journal-article" @default.
- W2004048256 hasAuthorship W2004048256A5000150124 @default.
- W2004048256 hasAuthorship W2004048256A5006728364 @default.
- W2004048256 hasAuthorship W2004048256A5016265229 @default.
- W2004048256 hasAuthorship W2004048256A5045266387 @default.