FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004049649> ?p ?o ?g. }

• W2004049649 endingPage "24591" @default.
• W2004049649 startingPage "24585" @default.
• W2004049649 abstract "The three-dimensional structure of the RNA-modifying enzyme, ψ55 tRNA pseudouridine synthase from Mycobacterium tuberculosis, is reported. The 1.9-Å resolution crystal structure reveals the enzyme, free of substrate, in two distinct conformations. The structure depicts an interesting mode of protein flexibility involving a hinged bending in the central β-sheet of the catalytic module. Key parts of the active site cleft are also found to be disordered in the substrate-free form of the enzyme. The hinge bending appears to act as a clamp to position the substrate. Our structural data furthers the previously proposed mechanism of tRNA recognition. The present crystal structure emphasizes the significant role that protein dynamics must play in tRNA recognition, base flipping, and modification. The three-dimensional structure of the RNA-modifying enzyme, ψ55 tRNA pseudouridine synthase from Mycobacterium tuberculosis, is reported. The 1.9-Å resolution crystal structure reveals the enzyme, free of substrate, in two distinct conformations. The structure depicts an interesting mode of protein flexibility involving a hinged bending in the central β-sheet of the catalytic module. Key parts of the active site cleft are also found to be disordered in the substrate-free form of the enzyme. The hinge bending appears to act as a clamp to position the substrate. Our structural data furthers the previously proposed mechanism of tRNA recognition. The present crystal structure emphasizes the significant role that protein dynamics must play in tRNA recognition, base flipping, and modification." @default.
• W2004049649 created "2016-06-24" @default.
• W2004049649 creator A5003664121 @default.
• W2004049649 creator A5045225459 @default.
• W2004049649 creator A5056419695 @default.
• W2004049649 creator A5078573155 @default.
• W2004049649 date "2004-06-01" @default.
• W2004049649 modified "2023-09-29" @default.
• W2004049649 title "Crystal Structure of the Apo Forms of ψ 55 tRNA Pseudouridine Synthase from Mycobacterium tuberculosis" @default.
• W2004049649 cites W12346750 @default.
• W2004049649 cites W1519739439 @default.
• W2004049649 cites W1536079196 @default.
• W2004049649 cites W1539796472 @default.
• W2004049649 cites W1917138181 @default.
• W2004049649 cites W1978683810 @default.
• W2004049649 cites W1986191025 @default.
• W2004049649 cites W1991154121 @default.
• W2004049649 cites W1994926187 @default.
• W2004049649 cites W1995017064 @default.
• W2004049649 cites W1995158072 @default.
• W2004049649 cites W1996607909 @default.
• W2004049649 cites W2001641653 @default.
• W2004049649 cites W2008708467 @default.
• W2004049649 cites W2013083986 @default.
• W2004049649 cites W2019832209 @default.
• W2004049649 cites W2021061167 @default.
• W2004049649 cites W2022058405 @default.
• W2004049649 cites W2028231353 @default.
• W2004049649 cites W2030016678 @default.
• W2004049649 cites W2032407233 @default.
• W2004049649 cites W2038840577 @default.
• W2004049649 cites W2048322955 @default.
• W2004049649 cites W2054735031 @default.
• W2004049649 cites W2069502553 @default.
• W2004049649 cites W2072734582 @default.
• W2004049649 cites W2079555125 @default.
• W2004049649 cites W2080476827 @default.
• W2004049649 cites W2086455009 @default.
• W2004049649 cites W2095084342 @default.
• W2004049649 cites W2100926646 @default.
• W2004049649 cites W2102993309 @default.
• W2004049649 cites W2105390414 @default.
• W2004049649 cites W2112200653 @default.
• W2004049649 cites W2129029102 @default.
• W2004049649 cites W2139691165 @default.
• W2004049649 cites W2152013697 @default.
• W2004049649 cites W2158789571 @default.
• W2004049649 cites W2159041982 @default.
• W2004049649 cites W2161261726 @default.
• W2004049649 cites W2164682441 @default.
• W2004049649 cites W2165011009 @default.
• W2004049649 doi "https://doi.org/10.1074/jbc.m401045200" @default.
• W2004049649 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15028724" @default.
• W2004049649 hasPublicationYear "2004" @default.
• W2004049649 type Work @default.
• W2004049649 sameAs 2004049649 @default.
• W2004049649 citedByCount "24" @default.
• W2004049649 countsByYear W20040496492013 @default.
• W2004049649 countsByYear W20040496492017 @default.
• W2004049649 countsByYear W20040496492020 @default.
• W2004049649 crossrefType "journal-article" @default.
• W2004049649 hasAuthorship W2004049649A5003664121 @default.
• W2004049649 hasAuthorship W2004049649A5045225459 @default.
• W2004049649 hasAuthorship W2004049649A5056419695 @default.
• W2004049649 hasAuthorship W2004049649A5078573155 @default.
• W2004049649 hasConcept C104317684 @default.
• W2004049649 hasConcept C153957851 @default.
• W2004049649 hasConcept C181199279 @default.
• W2004049649 hasConcept C185592680 @default.
• W2004049649 hasConcept C18903297 @default.
• W2004049649 hasConcept C2777289219 @default.
• W2004049649 hasConcept C2779810333 @default.
• W2004049649 hasConcept C2780120296 @default.
• W2004049649 hasConcept C41183919 @default.
• W2004049649 hasConcept C55493867 @default.
• W2004049649 hasConcept C67705224 @default.
• W2004049649 hasConcept C71240020 @default.
• W2004049649 hasConcept C8010536 @default.
• W2004049649 hasConcept C86803240 @default.
• W2004049649 hasConceptScore W2004049649C104317684 @default.
• W2004049649 hasConceptScore W2004049649C153957851 @default.
• W2004049649 hasConceptScore W2004049649C181199279 @default.
• W2004049649 hasConceptScore W2004049649C185592680 @default.
• W2004049649 hasConceptScore W2004049649C18903297 @default.
• W2004049649 hasConceptScore W2004049649C2777289219 @default.
• W2004049649 hasConceptScore W2004049649C2779810333 @default.
• W2004049649 hasConceptScore W2004049649C2780120296 @default.
• W2004049649 hasConceptScore W2004049649C41183919 @default.
• W2004049649 hasConceptScore W2004049649C55493867 @default.
• W2004049649 hasConceptScore W2004049649C67705224 @default.
• W2004049649 hasConceptScore W2004049649C71240020 @default.
• W2004049649 hasConceptScore W2004049649C8010536 @default.
• W2004049649 hasConceptScore W2004049649C86803240 @default.
• W2004049649 hasIssue "23" @default.
• W2004049649 hasLocation W20040496491 @default.
• W2004049649 hasOpenAccess W2004049649 @default.
• W2004049649 hasPrimaryLocation W20040496491 @default.
• W2004049649 hasRelatedWork W1499380138 @default.

• next