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- W2004051386 abstract "In 1996, Wang and his group empirically disclosed a key role of (deoxy)-ATP in functioning of the apoptotic machinery. After almost a decade, and despite the emerged intricacy of the death pathways, ATP is still considered a key determinant of apoptosis with no apparent active roles in necrosis. Yet recent findings indicate that apoptosis proceeds even without energy and that necrosis can be regulated by ATP-dependent processes. This review strictly focuses on current knowledge on the role of energy in execution of different death programs. A thorough understanding of energy requirements in cell death can help to overcome obsolete dogmas in cell biology, paving the way to a more integrated, albeit not simpler, view of the molecular mechanisms contributing to cell dismantling." @default.
- W2004051386 created "2016-06-24" @default.
- W2004051386 creator A5041992655 @default.
- W2004051386 date "2005-11-01" @default.
- W2004051386 modified "2023-09-23" @default.
- W2004051386 title "“Simple but not simpler”: toward a unified picture of energy requirements in cell death" @default.
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- W2004051386 doi "https://doi.org/10.1096/fj.05-4200rev" @default.
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