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- W2004052007 abstract "Objective: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals. Methods: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG. Results: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day. Conclusions: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation." @default.
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- W2004052007 date "2009-10-01" @default.
- W2004052007 modified "2023-09-27" @default.
- W2004052007 title "Association Between Fine Particulate Matter and Oxidative DNA Damage May Be Modified in Individuals With Hypertension" @default.
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- W2004052007 doi "https://doi.org/10.1097/jom.0b013e3181b967aa" @default.
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