FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004053759> ?p ?o ?g. }

• W2004053759 endingPage "48" @default.
• W2004053759 startingPage "31" @default.
• W2004053759 abstract "The mortality of septic shock in the pediatric population has improved over the last 2 decades with better supportive care however it still remains unacceptably high. Exaggerated inflammatory responses early in septic shock have been associated with poor outcomes. Regulation of the magnitude of the early inflammatory response is not well understood. The earliest aspect of the inflammatory response to pathogens is the innate immune response which is important to pathogen containment. Elements of the innate immune system activate the adaptive immune system in an antigen-specific way which leads to pathogen-specific protection and lasting immunologic memory to prevent subsequent infection. Pattern recognition receptors (PRRs) are evolutionarily conserved receptors on multiple types of innate immune cells and are capable of responding to highly conserved components of pathogens called pathogen associated molecular patterns (PAMPs). Numerous PRRs have been defined and are present on the cell surface as well as in the cytosol. These receptors fall into several classes called Toll-like receptors which are expressed on the cell surface or on the endosomal plasma membrane, C type lectin receptors and scavenger receptors which are only present on the cell surface. Other PRRs are present in the cytosol and including NOD-like receptors which can aggregate to form inflammasomes and RIG1 like receptors. Pathogenic microorganisms are extremely diverse however there are some common patterns repeated in components of structures such as the cell wall. PRRs can respond to PAMPs comprised of proteins, lipids, and carbohydrates, DNA and RNA. Numerous PAMPs have been described for many classes of pathogenic microorganisms such as Gram negative bacteria, Gram positive bacteria, viruses, fungi, and protozoa. The interactions between PRRs and PAMPs comprise the earliest immune responses to foreign substances and are critical for pathogen containment and amplification of the full repertoire of the immune response. There are developmental differences in the immune systems of infants and children compared to adults. The innate immune system matures much earlier than the adaptive immune response and as a result infants and young children may be more reliant on their innate immune system. For this reason it important to fully understand the key elements of the innate immune response including the many categories of PRRs and their cognate PAMPs. As these interactions are very early in the immune response, they are particularly relevant targets for therapeutic intervention. Below is a discussion of the major classes of PRRs, their expression, ligands, and signaling pathways as well as the major classes of PAMPs that activate them." @default.
• W2004053759 created "2016-06-24" @default.
• W2004053759 creator A5089649730 @default.
• W2004053759 date "2011-10-07" @default.
• W2004053759 modified "2023-09-26" @default.
• W2004053759 title "Pathogen Associated Molecular Patterns, Pattern Recognition Receptors and Pediatric Sepsis" @default.
• W2004053759 cites W1499978168 @default.
• W2004053759 cites W1512595753 @default.
• W2004053759 cites W1520365933 @default.
• W2004053759 cites W1529674879 @default.
• W2004053759 cites W1577886890 @default.
• W2004053759 cites W1607349291 @default.
• W2004053759 cites W1612465238 @default.
• W2004053759 cites W1894476426 @default.
• W2004053759 cites W1963802005 @default.
• W2004053759 cites W1964141567 @default.
• W2004053759 cites W1964718835 @default.
• W2004053759 cites W1966254238 @default.
• W2004053759 cites W1966312417 @default.
• W2004053759 cites W1966858538 @default.
• W2004053759 cites W1968869895 @default.
• W2004053759 cites W1969975290 @default.
• W2004053759 cites W1969987659 @default.
• W2004053759 cites W1970754628 @default.
• W2004053759 cites W1972754399 @default.
• W2004053759 cites W1975032025 @default.
• W2004053759 cites W1975475128 @default.
• W2004053759 cites W1977921022 @default.
• W2004053759 cites W1978274182 @default.
• W2004053759 cites W1979844428 @default.
• W2004053759 cites W1979991507 @default.
• W2004053759 cites W1987077580 @default.
• W2004053759 cites W1987463569 @default.
• W2004053759 cites W1988402030 @default.
• W2004053759 cites W1992540782 @default.
• W2004053759 cites W1995441274 @default.
• W2004053759 cites W1995744610 @default.
• W2004053759 cites W1996288898 @default.
• W2004053759 cites W1997252077 @default.
• W2004053759 cites W1998348567 @default.
• W2004053759 cites W1999164035 @default.
• W2004053759 cites W1999618801 @default.
• W2004053759 cites W2001883479 @default.
• W2004053759 cites W2001904356 @default.
• W2004053759 cites W2004312418 @default.
• W2004053759 cites W2004465286 @default.
• W2004053759 cites W2004487653 @default.
• W2004053759 cites W2007058937 @default.
• W2004053759 cites W2008808919 @default.
• W2004053759 cites W2009004909 @default.
• W2004053759 cites W2010683661 @default.
• W2004053759 cites W2012193854 @default.
• W2004053759 cites W2013038545 @default.
• W2004053759 cites W2016503643 @default.
• W2004053759 cites W2016862474 @default.
• W2004053759 cites W2018072316 @default.
• W2004053759 cites W2020355720 @default.
• W2004053759 cites W2024549315 @default.
• W2004053759 cites W2025291853 @default.
• W2004053759 cites W2028575270 @default.
• W2004053759 cites W2028792773 @default.
• W2004053759 cites W2031269216 @default.
• W2004053759 cites W2037493138 @default.
• W2004053759 cites W2038538882 @default.
• W2004053759 cites W2039807525 @default.
• W2004053759 cites W2040024879 @default.
• W2004053759 cites W2040853949 @default.
• W2004053759 cites W2042183374 @default.
• W2004053759 cites W2042433863 @default.
• W2004053759 cites W2043667001 @default.
• W2004053759 cites W2044210137 @default.
• W2004053759 cites W2045279953 @default.
• W2004053759 cites W2047525024 @default.
• W2004053759 cites W2048000602 @default.
• W2004053759 cites W2049361955 @default.
• W2004053759 cites W2050293120 @default.
• W2004053759 cites W2050361028 @default.
• W2004053759 cites W2051026238 @default.
• W2004053759 cites W2052106057 @default.
• W2004053759 cites W2055960613 @default.
• W2004053759 cites W2055975107 @default.
• W2004053759 cites W2059584632 @default.
• W2004053759 cites W2062328476 @default.
• W2004053759 cites W2062882143 @default.
• W2004053759 cites W2063062764 @default.
• W2004053759 cites W2064044173 @default.
• W2004053759 cites W2065554630 @default.
• W2004053759 cites W2066904343 @default.
• W2004053759 cites W2068754184 @default.
• W2004053759 cites W2069502810 @default.
• W2004053759 cites W2069663822 @default.
• W2004053759 cites W2072018350 @default.
• W2004053759 cites W2075145828 @default.
• W2004053759 cites W2075583035 @default.
• W2004053759 cites W2075984975 @default.
• W2004053759 cites W2076361525 @default.
• W2004053759 cites W2079357488 @default.
• W2004053759 cites W2080287136 @default.

• next