FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004057100> ?p ?o ?g. }

• W2004057100 endingPage "823" @default.
• W2004057100 startingPage "818" @default.
• W2004057100 abstract "Organic anion transporting polypeptide 1B3 (OATP1B3) is a hepatocyte plasma membrane protein that transports various endogenous and xenobiotic compounds. Although it is exclusively expressed in the human liver under normal conditions, OATP1B3 can be also expressed in various human cancer tissues that have been associated with prognosis and clinical outcomes. However, despite the potential significance of the latter finding, no experimental evidence addressing the molecular entity of cancer-associated OATP1B3 has been provided to date. In this paper, we report the identification of a new OATP1B3 mRNA isoform expressed in human colon and lung cancer tissues, which we named cancer-type OATP1B3 (Ct-OATP1B3). Our results also make known a previously unidentified transcription start site and an alternative promoter region, localized at intron 2, from which Ct-OATP1B3 mRNA is generated. Isoform specific mRNA quantification showed that the Ct-OATP1B3 mRNA level was strikingly higher than that of Lt-OATP1B3 mRNA in human cancer tissues. In addition, the results showed that the translation occurred at three out of four open reading frames. To summarize, our results clearly demonstrate that the newly-identified Ct-OATP1B3 (but not Lt-OATP1B3) is the primary mRNA isoform, at least in the human cancerous samples we have examined. In line with the possibility that its translation products play important biological roles in cancer cells, we strongly believe that the existence of Ct-OATP1B3 should be taken into account during future studies of OATP1B3 associated with cancer prognosis and clinical outcomes." @default.
• W2004057100 created "2016-06-24" @default.
• W2004057100 creator A5002077421 @default.
• W2004057100 creator A5012309005 @default.
• W2004057100 creator A5019832401 @default.
• W2004057100 creator A5021126113 @default.
• W2004057100 creator A5024470863 @default.
• W2004057100 creator A5030864419 @default.
• W2004057100 creator A5041358310 @default.
• W2004057100 creator A5054732344 @default.
• W2004057100 creator A5062376392 @default.
• W2004057100 creator A5069121285 @default.
• W2004057100 date "2012-02-01" @default.
• W2004057100 modified "2023-10-09" @default.
• W2004057100 title "Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells" @default.
• W2004057100 cites W1964411566 @default.
• W2004057100 cites W1967841068 @default.
• W2004057100 cites W1975619680 @default.
• W2004057100 cites W1992810557 @default.
• W2004057100 cites W1997601514 @default.
• W2004057100 cites W2011295463 @default.
• W2004057100 cites W2025609844 @default.
• W2004057100 cites W2065498897 @default.
• W2004057100 cites W2091234451 @default.
• W2004057100 cites W2101108570 @default.
• W2004057100 cites W2110004994 @default.
• W2004057100 cites W2111987374 @default.
• W2004057100 cites W2112067247 @default.
• W2004057100 cites W2131887570 @default.
• W2004057100 cites W2147039462 @default.
• W2004057100 cites W2167450468 @default.
• W2004057100 cites W2169468059 @default.
• W2004057100 doi "https://doi.org/10.1016/j.bbrc.2012.01.115" @default.
• W2004057100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22326869" @default.
• W2004057100 hasPublicationYear "2012" @default.
• W2004057100 type Work @default.
• W2004057100 sameAs 2004057100 @default.
• W2004057100 citedByCount "59" @default.
• W2004057100 countsByYear W20040571002012 @default.
• W2004057100 countsByYear W20040571002013 @default.
• W2004057100 countsByYear W20040571002014 @default.
• W2004057100 countsByYear W20040571002015 @default.
• W2004057100 countsByYear W20040571002016 @default.
• W2004057100 countsByYear W20040571002017 @default.
• W2004057100 countsByYear W20040571002018 @default.
• W2004057100 countsByYear W20040571002019 @default.
• W2004057100 countsByYear W20040571002020 @default.
• W2004057100 countsByYear W20040571002021 @default.
• W2004057100 countsByYear W20040571002022 @default.
• W2004057100 countsByYear W20040571002023 @default.
• W2004057100 crossrefType "journal-article" @default.
• W2004057100 hasAuthorship W2004057100A5002077421 @default.
• W2004057100 hasAuthorship W2004057100A5012309005 @default.
• W2004057100 hasAuthorship W2004057100A5019832401 @default.
• W2004057100 hasAuthorship W2004057100A5021126113 @default.
• W2004057100 hasAuthorship W2004057100A5024470863 @default.
• W2004057100 hasAuthorship W2004057100A5030864419 @default.
• W2004057100 hasAuthorship W2004057100A5041358310 @default.
• W2004057100 hasAuthorship W2004057100A5054732344 @default.
• W2004057100 hasAuthorship W2004057100A5062376392 @default.
• W2004057100 hasAuthorship W2004057100A5069121285 @default.
• W2004057100 hasConcept C104317684 @default.
• W2004057100 hasConcept C105580179 @default.
• W2004057100 hasConcept C121608353 @default.
• W2004057100 hasConcept C123584848 @default.
• W2004057100 hasConcept C149011108 @default.
• W2004057100 hasConcept C149364088 @default.
• W2004057100 hasConcept C153911025 @default.
• W2004057100 hasConcept C2776678969 @default.
• W2004057100 hasConcept C53345823 @default.
• W2004057100 hasConcept C54355233 @default.
• W2004057100 hasConcept C55493867 @default.
• W2004057100 hasConcept C86803240 @default.
• W2004057100 hasConceptScore W2004057100C104317684 @default.
• W2004057100 hasConceptScore W2004057100C105580179 @default.
• W2004057100 hasConceptScore W2004057100C121608353 @default.
• W2004057100 hasConceptScore W2004057100C123584848 @default.
• W2004057100 hasConceptScore W2004057100C149011108 @default.
• W2004057100 hasConceptScore W2004057100C149364088 @default.
• W2004057100 hasConceptScore W2004057100C153911025 @default.
• W2004057100 hasConceptScore W2004057100C2776678969 @default.
• W2004057100 hasConceptScore W2004057100C53345823 @default.
• W2004057100 hasConceptScore W2004057100C54355233 @default.
• W2004057100 hasConceptScore W2004057100C55493867 @default.
• W2004057100 hasConceptScore W2004057100C86803240 @default.
• W2004057100 hasFunder F4320320912 @default.
• W2004057100 hasIssue "4" @default.
• W2004057100 hasLocation W20040571001 @default.
• W2004057100 hasLocation W20040571002 @default.
• W2004057100 hasOpenAccess W2004057100 @default.
• W2004057100 hasPrimaryLocation W20040571001 @default.
• W2004057100 hasRelatedWork W1906327586 @default.
• W2004057100 hasRelatedWork W1980410422 @default.
• W2004057100 hasRelatedWork W2015755153 @default.
• W2004057100 hasRelatedWork W2104908006 @default.
• W2004057100 hasRelatedWork W2117675164 @default.
• W2004057100 hasRelatedWork W2130446470 @default.
• W2004057100 hasRelatedWork W2171167058 @default.

• next