FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004058848> ?p ?o ?g. }

• W2004058848 endingPage "S61" @default.
• W2004058848 startingPage "S56" @default.
• W2004058848 abstract "Left ventricular hypertrophy (LVH) is regarded as a complication common to a number of cardiovascular diseases, including hypertension, myocardial infarction and ischaemia associated with coronary artery disease. Initially LVH is a compensatory mechanism, but in the long term cardiac hypertrophy predisposes individuals to heart failure, myocardial infarction and sudden death. Alteration of the nitric oxide (NO) pathway is believed to play an important role in the haemodynamically overloaded heart and pathological cardiac remodelling. Although re-establishment of the physiological NO pathway could be considered an important therapeutic target, the use of conventional nitrates is limited in the clinical setting by the development of tissue resistance and tolerance and by the shortage of large-scale clinical trials unequivocally confirming the beneficial impact of NO donors on cardiovascular morbidity and mortality. The aim of this review is to present current therapeutic options for dealing with changes in the L-arginine-NO pathway. The most promising therapeutic approach is represented by a new neutral sugar organic nitrate, LA-419, the thiol group of which seems to protect NO from degradation, thereby increasing its bioavailability. In a model of aortic stenosis-induced pressure overload, LA-419 has been found to restore the complete NO signalling cascade and reduce left ventricular remodelling, but without restoring the original pressure gradient, indicating a possible direct antiproliferative effect. Future studies are needed to confirm this therapeutic benefit in other animal models of hypertension and in the clinical setting." @default.
• W2004058848 created "2016-06-24" @default.
• W2004058848 creator A5011947633 @default.
• W2004058848 creator A5030833355 @default.
• W2004058848 date "2010-09-01" @default.
• W2004058848 modified "2023-10-01" @default.
• W2004058848 title "Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors" @default.
• W2004058848 cites W1583086572 @default.
• W2004058848 cites W1967088057 @default.
• W2004058848 cites W1972879419 @default.
• W2004058848 cites W1978545009 @default.
• W2004058848 cites W1985889471 @default.
• W2004058848 cites W1990215202 @default.
• W2004058848 cites W1990303174 @default.
• W2004058848 cites W1990738801 @default.
• W2004058848 cites W1991074341 @default.
• W2004058848 cites W2000765231 @default.
• W2004058848 cites W2003102975 @default.
• W2004058848 cites W2003630942 @default.
• W2004058848 cites W2004177921 @default.
• W2004058848 cites W2006657380 @default.
• W2004058848 cites W2012244194 @default.
• W2004058848 cites W2015379716 @default.
• W2004058848 cites W2021197623 @default.
• W2004058848 cites W2038527687 @default.
• W2004058848 cites W2040643466 @default.
• W2004058848 cites W2046949827 @default.
• W2004058848 cites W2052313932 @default.
• W2004058848 cites W2063345890 @default.
• W2004058848 cites W2065988240 @default.
• W2004058848 cites W2080679910 @default.
• W2004058848 cites W2088722428 @default.
• W2004058848 cites W2090391107 @default.
• W2004058848 cites W2091592969 @default.
• W2004058848 cites W2104675226 @default.
• W2004058848 cites W2107031860 @default.
• W2004058848 cites W2112439550 @default.
• W2004058848 cites W2112923281 @default.
• W2004058848 cites W2115693238 @default.
• W2004058848 cites W2118462346 @default.
• W2004058848 cites W2120408669 @default.
• W2004058848 cites W2131032991 @default.
• W2004058848 cites W2131839071 @default.
• W2004058848 cites W2134080458 @default.
• W2004058848 cites W2142242002 @default.
• W2004058848 cites W2143199174 @default.
• W2004058848 cites W2146624681 @default.
• W2004058848 cites W2161430861 @default.
• W2004058848 cites W2171466485 @default.
• W2004058848 cites W2171984608 @default.
• W2004058848 cites W2323206538 @default.
• W2004058848 cites W2334499091 @default.
• W2004058848 cites W59187678 @default.
• W2004058848 doi "https://doi.org/10.1097/01.hjh.0000388496.66330.b8" @default.
• W2004058848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20823718" @default.
• W2004058848 hasPublicationYear "2010" @default.
• W2004058848 type Work @default.
• W2004058848 sameAs 2004058848 @default.
• W2004058848 citedByCount "20" @default.
• W2004058848 countsByYear W20040588482012 @default.
• W2004058848 countsByYear W20040588482013 @default.
• W2004058848 countsByYear W20040588482014 @default.
• W2004058848 countsByYear W20040588482016 @default.
• W2004058848 countsByYear W20040588482017 @default.
• W2004058848 countsByYear W20040588482018 @default.
• W2004058848 countsByYear W20040588482019 @default.
• W2004058848 countsByYear W20040588482020 @default.
• W2004058848 countsByYear W20040588482021 @default.
• W2004058848 countsByYear W20040588482022 @default.
• W2004058848 countsByYear W20040588482023 @default.
• W2004058848 crossrefType "journal-article" @default.
• W2004058848 hasAuthorship W2004058848A5011947633 @default.
• W2004058848 hasAuthorship W2004058848A5030833355 @default.
• W2004058848 hasConcept C126322002 @default.
• W2004058848 hasConcept C164705383 @default.
• W2004058848 hasConcept C2776002628 @default.
• W2004058848 hasConcept C2778198053 @default.
• W2004058848 hasConcept C2778213512 @default.
• W2004058848 hasConcept C2778271984 @default.
• W2004058848 hasConcept C2780930700 @default.
• W2004058848 hasConcept C3018791406 @default.
• W2004058848 hasConcept C500558357 @default.
• W2004058848 hasConcept C519581460 @default.
• W2004058848 hasConcept C71924100 @default.
• W2004058848 hasConcept C84393581 @default.
• W2004058848 hasConceptScore W2004058848C126322002 @default.
• W2004058848 hasConceptScore W2004058848C164705383 @default.
• W2004058848 hasConceptScore W2004058848C2776002628 @default.
• W2004058848 hasConceptScore W2004058848C2778198053 @default.
• W2004058848 hasConceptScore W2004058848C2778213512 @default.
• W2004058848 hasConceptScore W2004058848C2778271984 @default.
• W2004058848 hasConceptScore W2004058848C2780930700 @default.
• W2004058848 hasConceptScore W2004058848C3018791406 @default.
• W2004058848 hasConceptScore W2004058848C500558357 @default.
• W2004058848 hasConceptScore W2004058848C519581460 @default.
• W2004058848 hasConceptScore W2004058848C71924100 @default.
• W2004058848 hasConceptScore W2004058848C84393581 @default.
• W2004058848 hasIssue "Suppl 1" @default.

• next