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- W2004062023 abstract "Pnrophylaxis against diphtheria is universally recommended; prophylaxis against whooping cough is now generally accepted; and prophylaxis against tetanus has been found effective, although it has not been used routinely. The combined prophylaxis against two of the three diseases—diphtheria and tetanus—has been in use for several years.1This paper records my experience with the combined prophylaxis against the three diseases—diphtheria, tetanus and whooping cough. Theoretically, this triple immunization would present two advantages: first, possible adsorption of the toxoids and toxins by bacterial suspension, thus affording what Ramon2has called a larger effective surface; second, nonspecific enhancement of antigen production, termed by Ramon antigenic synergy. As an example of enhancement produced by the mixture of a toxoid with a bacterial vaccine, the work of Schutze3is of interest. He immunized guinea pigs with mixtures of alum-precipitated diphtheria toxoid and whooping cough vaccine and reported the" @default.
- W2004062023 created "2016-06-24" @default.
- W2004062023 creator A5007259057 @default.
- W2004062023 date "1942-02-01" @default.
- W2004062023 modified "2023-09-25" @default.
- W2004062023 title "COMBINED IMMUNIZATION OF INFANTS AGAINST DIPHTHERIA, TETANUS AND WHOOPING COUGH" @default.
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- W2004062023 doi "https://doi.org/10.1001/archpedi.1942.02010020010002" @default.
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