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- W2004068872 abstract "γ/δ T cells represent a subset of T cells expressing a T cell receptor (TCR) variant composed of gamma and delta chains. The γ/δ TCR is expressed by 2–10% of all T cells in human peripheral blood, whereas the majority of T cells express α/β TCRs. γ/δ T cells display a range of innate effector functions including rapid secretion of chemokines and cytokines, as well as target cell lysis. Recent interest has focused on the function of γ/δ T lymphocytes in allogeneic transplantation in the onco-hematology field. Several studies, in vitro and in vivo, suggest that γ/δ T lymphocytes are potential beneficial effector cells in the context of hematopoietic stem cell transplantation (HSCT). In addition, in this review, we discuss the depletion of α/β T lymphocytes in the graft for allogeneic transplantation. In fact, an efficient TCR α/β cell depletion potentially reduces the risk of GvHD. Furthermore, TCR α/β T cell depletion, especially with immunomagnetic negative selection, retains other potential beneficial effector cells in the graft, such as γ/δ T cells, NK cells, and stem cells. These “facilitating” cells might facilitate engraftment, exert GvL effects, and reduce the risk for infections." @default.
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- W2004068872 date "2012-02-01" @default.
- W2004068872 modified "2023-10-07" @default.
- W2004068872 title "Transplantation in the onco-hematology field: Focus on the manipulation of αβ and γδ T cells" @default.
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- W2004068872 doi "https://doi.org/10.1016/j.prp.2011.10.006" @default.
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