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• W2004069864 abstract "Pax-6 is essential for normal eye development and has been implicated as a master gene for lens formation in embryogenesis. Guinea pig zeta-crystallin, a taxon-specific enzyme crystallin, achieves high expression specifically in lens through use of an alternative promoter. Here we show that Pax-6 binds a site in this promoter, which is essential for lens-specific expression. Lens and lens-derived cells exhibit a tissue-specific pattern of alternative splicing of Pax-6 transcripts and Pax-6 is expressed in adult lenses and cells that support zeta-crystallin expression. These results suggest that zeta-crystallin is a natural target gene for Pax-6 and that this Pax family member has a direct role in the continuing expression of tissue-specific genes." @default.
• W2004069864 created "2016-06-24" @default.
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• W2004069864 date "1995-05-09" @default.
• W2004069864 modified "2023-10-18" @default.
• W2004069864 title "Pax-6 is essential for lens-specific expression of zeta-crystallin." @default.
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• W2004069864 doi "https://doi.org/10.1073/pnas.92.10.4676" @default.
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