Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004077897> ?p ?o ?g. }
- W2004077897 endingPage "400" @default.
- W2004077897 startingPage "387" @default.
- W2004077897 abstract "Several human channelopathies result from mutations in alpha1A, the pore-forming subunit of P/Q-type Ca2+ channels, conduits of presynaptic Ca2+ entry for evoked neurotransmission. We found that wild-type human alpha1A subunits supported transmission between cultured mouse hippocampal neurons equally well as endogenous mouse alpha1A, whereas introduction of impermeant human alpha1A hampered the effect of endogenous subunits. Thus, presynaptic P/Q-type channels may compete for channel type-preferring slots that limit their synaptic effectiveness. The existence of slots generates predictions for how neurotransmission might be affected by changes in Ca2+ channel properties, which we tested by studying alpha1A mutations that are associated with familial hemiplegic migraine type 1 (FHM1). Mutant human P/Q-type channels were impaired in contributing to neurotransmission in precise accord with their deficiency in supporting whole-cell Ca2+ channel activity. Expression of mutant channels in wild-type neurons reduced the synaptic contribution of P/Q-type channels, suggesting that competition for type-preferring slots might support the dominant inheritance of FHM1." @default.
- W2004077897 created "2016-06-24" @default.
- W2004077897 creator A5001371257 @default.
- W2004077897 creator A5013206646 @default.
- W2004077897 creator A5014493479 @default.
- W2004077897 creator A5028006387 @default.
- W2004077897 creator A5045550508 @default.
- W2004077897 creator A5090142352 @default.
- W2004077897 date "2004-08-01" @default.
- W2004077897 modified "2023-10-15" @default.
- W2004077897 title "Presynaptic Ca2+ Channels Compete for Channel Type-Preferring Slots in Altered Neurotransmission Arising from Ca2+ Channelopathy" @default.
- W2004077897 cites W1487299688 @default.
- W2004077897 cites W1503053719 @default.
- W2004077897 cites W1546762987 @default.
- W2004077897 cites W1595570385 @default.
- W2004077897 cites W1798409403 @default.
- W2004077897 cites W1859463348 @default.
- W2004077897 cites W1968031522 @default.
- W2004077897 cites W1969308562 @default.
- W2004077897 cites W1971844027 @default.
- W2004077897 cites W1973556415 @default.
- W2004077897 cites W1975458358 @default.
- W2004077897 cites W1976817332 @default.
- W2004077897 cites W1979957972 @default.
- W2004077897 cites W1980325410 @default.
- W2004077897 cites W1983169741 @default.
- W2004077897 cites W1988937009 @default.
- W2004077897 cites W1994123659 @default.
- W2004077897 cites W1996618398 @default.
- W2004077897 cites W1996629542 @default.
- W2004077897 cites W1998518207 @default.
- W2004077897 cites W2014234114 @default.
- W2004077897 cites W2020479551 @default.
- W2004077897 cites W2025197615 @default.
- W2004077897 cites W2030034627 @default.
- W2004077897 cites W2032255062 @default.
- W2004077897 cites W2032491229 @default.
- W2004077897 cites W2039994681 @default.
- W2004077897 cites W2040271533 @default.
- W2004077897 cites W2042289944 @default.
- W2004077897 cites W2048527331 @default.
- W2004077897 cites W2052258972 @default.
- W2004077897 cites W2054605659 @default.
- W2004077897 cites W2057012057 @default.
- W2004077897 cites W2061225022 @default.
- W2004077897 cites W2063829584 @default.
- W2004077897 cites W2065391976 @default.
- W2004077897 cites W2068604808 @default.
- W2004077897 cites W2075030357 @default.
- W2004077897 cites W2075174600 @default.
- W2004077897 cites W2090116059 @default.
- W2004077897 cites W2090157435 @default.
- W2004077897 cites W2098037389 @default.
- W2004077897 cites W2110095865 @default.
- W2004077897 cites W2111849736 @default.
- W2004077897 cites W2114454477 @default.
- W2004077897 cites W2116851540 @default.
- W2004077897 cites W2123988448 @default.
- W2004077897 cites W2125723241 @default.
- W2004077897 cites W2125877971 @default.
- W2004077897 cites W2138512124 @default.
- W2004077897 cites W2141732701 @default.
- W2004077897 cites W2143416389 @default.
- W2004077897 cites W2149394947 @default.
- W2004077897 cites W2153704590 @default.
- W2004077897 cites W2158561409 @default.
- W2004077897 cites W2165044614 @default.
- W2004077897 cites W2323637940 @default.
- W2004077897 cites W4252866398 @default.
- W2004077897 cites W4317639526 @default.
- W2004077897 cites W4317639556 @default.
- W2004077897 cites W4321429487 @default.
- W2004077897 doi "https://doi.org/10.1016/j.neuron.2004.07.014" @default.
- W2004077897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15294146" @default.
- W2004077897 hasPublicationYear "2004" @default.
- W2004077897 type Work @default.
- W2004077897 sameAs 2004077897 @default.
- W2004077897 citedByCount "161" @default.
- W2004077897 countsByYear W20040778972012 @default.
- W2004077897 countsByYear W20040778972013 @default.
- W2004077897 countsByYear W20040778972014 @default.
- W2004077897 countsByYear W20040778972015 @default.
- W2004077897 countsByYear W20040778972016 @default.
- W2004077897 countsByYear W20040778972017 @default.
- W2004077897 countsByYear W20040778972018 @default.
- W2004077897 countsByYear W20040778972019 @default.
- W2004077897 countsByYear W20040778972020 @default.
- W2004077897 countsByYear W20040778972021 @default.
- W2004077897 countsByYear W20040778972022 @default.
- W2004077897 countsByYear W20040778972023 @default.
- W2004077897 crossrefType "journal-article" @default.
- W2004077897 hasAuthorship W2004077897A5001371257 @default.
- W2004077897 hasAuthorship W2004077897A5013206646 @default.
- W2004077897 hasAuthorship W2004077897A5014493479 @default.
- W2004077897 hasAuthorship W2004077897A5028006387 @default.
- W2004077897 hasAuthorship W2004077897A5045550508 @default.
- W2004077897 hasAuthorship W2004077897A5090142352 @default.
- W2004077897 hasBestOaLocation W20040778971 @default.