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• W2004079119 abstract "Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of neurological disorders and subclinical brain dysfunction. One of the best known neurotoxins is methylmercury (MeHg), a ubiquitous environmental toxicant that leads to long-lasting neurological and developmental deficits in animals and humans. In the aquatic environment, MeHg is accumulated in fish, which represent a major source of human exposure. Although several episodes of MeHg poisoning have contributed to the understanding of the clinical symptoms and histological changes elicited by this neurotoxicant in humans, experimental studies have been pivotal in elucidating the molecular mechanisms that mediate MeHg-induced neurotoxicity. The objective of this mini-review is to summarize data from experimental studies on molecular mechanisms of MeHg-induced neurotoxicity. While the full picture has yet to be unmasked, in vitro approaches based on cultured cells, isolated mitochondria and tissue slices, as well as in vivo studies based mainly on the use of rodents, point to impairment in intracellular calcium homeostasis, alteration of glutamate homeostasis and oxidative stress as important events in MeHg-induced neurotoxicity. The potential relationship among these events is discussed, with particular emphasis on the neurotoxic cycle triggered by MeHg-induced excitotoxicity and oxidative stress. The particular sensitivity of the developing brain to MeHg toxicity, the critical role of selenoproteins and the potential protective role of selenocompounds are also discussed. These concepts provide the biochemical bases to the understanding of MeHg neurotoxicity, contributing to the discovery of endogenous and exogenous molecules that counteract such toxicity and provide efficacious means for ablating this vicious cycle." @default.
• W2004079119 created "2016-06-24" @default.
• W2004079119 creator A5014804546 @default.
• W2004079119 creator A5035503566 @default.
• W2004079119 creator A5051428255 @default.
• W2004079119 date "2011-10-01" @default.
• W2004079119 modified "2023-10-10" @default.
• W2004079119 title "Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies" @default.
• W2004079119 cites W1711976313 @default.
• W2004079119 cites W1892844118 @default.
• W2004079119 cites W1909841186 @default.
• W2004079119 cites W1914397099 @default.
• W2004079119 cites W1963487339 @default.
• W2004079119 cites W1963517028 @default.
• W2004079119 cites W1965354567 @default.
• W2004079119 cites W1965476204 @default.
• W2004079119 cites W1966988500 @default.
• W2004079119 cites W1970827624 @default.
• W2004079119 cites W1973101262 @default.
• W2004079119 cites W1975082982 @default.
• W2004079119 cites W1976289522 @default.
• W2004079119 cites W1977428199 @default.
• W2004079119 cites W1978348298 @default.
• W2004079119 cites W1978940266 @default.
• W2004079119 cites W1980976762 @default.
• W2004079119 cites W1981784563 @default.
• W2004079119 cites W1988152888 @default.
• W2004079119 cites W1991560579 @default.
• W2004079119 cites W1994238140 @default.
• W2004079119 cites W1994247568 @default.
• W2004079119 cites W1995019025 @default.
• W2004079119 cites W1998290119 @default.
• W2004079119 cites W1999619268 @default.
• W2004079119 cites W2000344900 @default.
• W2004079119 cites W2004606133 @default.
• W2004079119 cites W2005930244 @default.
• W2004079119 cites W2006689480 @default.
• W2004079119 cites W2009332153 @default.
• W2004079119 cites W2010430191 @default.
• W2004079119 cites W2011377979 @default.
• W2004079119 cites W2011822918 @default.
• W2004079119 cites W2012550963 @default.
• W2004079119 cites W2013706308 @default.
• W2004079119 cites W2014003517 @default.
• W2004079119 cites W2019008376 @default.
• W2004079119 cites W2019887385 @default.
• W2004079119 cites W2022469689 @default.
• W2004079119 cites W2023219896 @default.
• W2004079119 cites W2026401025 @default.
• W2004079119 cites W2029872554 @default.
• W2004079119 cites W2031754719 @default.
• W2004079119 cites W2032374968 @default.
• W2004079119 cites W2033296858 @default.
• W2004079119 cites W2038702983 @default.
• W2004079119 cites W2039413275 @default.
• W2004079119 cites W2040330912 @default.
• W2004079119 cites W2042173936 @default.
• W2004079119 cites W2042268520 @default.
• W2004079119 cites W2043375002 @default.
• W2004079119 cites W2049505012 @default.
• W2004079119 cites W2050452327 @default.
• W2004079119 cites W2050532538 @default.
• W2004079119 cites W2052021812 @default.
• W2004079119 cites W2052598520 @default.
• W2004079119 cites W2053956211 @default.
• W2004079119 cites W2056205471 @default.
• W2004079119 cites W2060440850 @default.
• W2004079119 cites W2060756354 @default.
• W2004079119 cites W2062361496 @default.
• W2004079119 cites W2064569222 @default.
• W2004079119 cites W2064857569 @default.
• W2004079119 cites W2065699023 @default.
• W2004079119 cites W2065842319 @default.
• W2004079119 cites W2066071804 @default.
• W2004079119 cites W2066935304 @default.
• W2004079119 cites W2067114364 @default.
• W2004079119 cites W2068713188 @default.
• W2004079119 cites W2068722115 @default.
• W2004079119 cites W2070134581 @default.
• W2004079119 cites W2072926617 @default.
• W2004079119 cites W2074206560 @default.
• W2004079119 cites W2074409546 @default.
• W2004079119 cites W2075010922 @default.
• W2004079119 cites W2075128291 @default.
• W2004079119 cites W2076649634 @default.
• W2004079119 cites W2078388448 @default.
• W2004079119 cites W2079135882 @default.
• W2004079119 cites W2080203024 @default.
• W2004079119 cites W2082128802 @default.
• W2004079119 cites W2082851670 @default.
• W2004079119 cites W2084817190 @default.
• W2004079119 cites W2085430333 @default.
• W2004079119 cites W2085640881 @default.
• W2004079119 cites W2088874491 @default.
• W2004079119 cites W2089525125 @default.
• W2004079119 cites W2093150351 @default.
• W2004079119 cites W2094336185 @default.
• W2004079119 cites W2094673836 @default.

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