Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004082485> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2004082485 endingPage "57" @default.
- W2004082485 startingPage "49" @default.
- W2004082485 abstract "The problem of finding the optimal regulatory structures was formulated as a mixed-integer linear programming problem for lysine synthetic pathway using (log)linear models obtained from nonlinear kinetic models developed previously by us. Optimal structures were obtained from a set of postulated regulatory structures. This method of metabolic design allowed the identification of the type and the strength of the necessary regulations, the activities of the corresponding enzymes and the intermediate metabolite levels in the lysine pathway. The calculated results indicate that >20% increase of the internal lysine flux can be obtained when only the inhibitory regulation was allowed, and eight optimal structures with one regulatory loop were adopted. When the regulation due to enzyme activation was allowed, the internal lysine flux can be increased by >70%. Changes of the participating precursor and cofactor concentrations may not improve the lysine flux significantly in this system." @default.
- W2004082485 created "2016-06-24" @default.
- W2004082485 creator A5003459068 @default.
- W2004082485 creator A5045803827 @default.
- W2004082485 creator A5067288478 @default.
- W2004082485 date "2001-11-01" @default.
- W2004082485 modified "2023-10-18" @default.
- W2004082485 title "Design of metabolic regulatory structures for enhanced lysine synthesis flux using (log)linearized kinetic models" @default.
- W2004082485 cites W1536406986 @default.
- W2004082485 cites W1583063357 @default.
- W2004082485 cites W1969529366 @default.
- W2004082485 cites W2004603692 @default.
- W2004082485 cites W2016140326 @default.
- W2004082485 cites W2020241931 @default.
- W2004082485 cites W2034645234 @default.
- W2004082485 cites W2044189879 @default.
- W2004082485 cites W2049167322 @default.
- W2004082485 cites W2062245653 @default.
- W2004082485 cites W2062573363 @default.
- W2004082485 cites W2068918169 @default.
- W2004082485 cites W2073311475 @default.
- W2004082485 cites W2081484705 @default.
- W2004082485 cites W2120095985 @default.
- W2004082485 cites W2126334841 @default.
- W2004082485 cites W2147454875 @default.
- W2004082485 cites W4232054163 @default.
- W2004082485 doi "https://doi.org/10.1016/s1369-703x(01)00125-5" @default.
- W2004082485 hasPublicationYear "2001" @default.
- W2004082485 type Work @default.
- W2004082485 sameAs 2004082485 @default.
- W2004082485 citedByCount "2" @default.
- W2004082485 countsByYear W20040824852020 @default.
- W2004082485 crossrefType "journal-article" @default.
- W2004082485 hasAuthorship W2004082485A5003459068 @default.
- W2004082485 hasAuthorship W2004082485A5045803827 @default.
- W2004082485 hasAuthorship W2004082485A5067288478 @default.
- W2004082485 hasConcept C121332964 @default.
- W2004082485 hasConcept C135889238 @default.
- W2004082485 hasConcept C154945302 @default.
- W2004082485 hasConcept C158622935 @default.
- W2004082485 hasConcept C178790620 @default.
- W2004082485 hasConcept C181199279 @default.
- W2004082485 hasConcept C185592680 @default.
- W2004082485 hasConcept C186060115 @default.
- W2004082485 hasConcept C192989942 @default.
- W2004082485 hasConcept C197957613 @default.
- W2004082485 hasConcept C2775924081 @default.
- W2004082485 hasConcept C2776016237 @default.
- W2004082485 hasConcept C2777477808 @default.
- W2004082485 hasConcept C41008148 @default.
- W2004082485 hasConcept C47446073 @default.
- W2004082485 hasConcept C515207424 @default.
- W2004082485 hasConcept C55493867 @default.
- W2004082485 hasConcept C62520636 @default.
- W2004082485 hasConcept C68709404 @default.
- W2004082485 hasConcept C86803240 @default.
- W2004082485 hasConceptScore W2004082485C121332964 @default.
- W2004082485 hasConceptScore W2004082485C135889238 @default.
- W2004082485 hasConceptScore W2004082485C154945302 @default.
- W2004082485 hasConceptScore W2004082485C158622935 @default.
- W2004082485 hasConceptScore W2004082485C178790620 @default.
- W2004082485 hasConceptScore W2004082485C181199279 @default.
- W2004082485 hasConceptScore W2004082485C185592680 @default.
- W2004082485 hasConceptScore W2004082485C186060115 @default.
- W2004082485 hasConceptScore W2004082485C192989942 @default.
- W2004082485 hasConceptScore W2004082485C197957613 @default.
- W2004082485 hasConceptScore W2004082485C2775924081 @default.
- W2004082485 hasConceptScore W2004082485C2776016237 @default.
- W2004082485 hasConceptScore W2004082485C2777477808 @default.
- W2004082485 hasConceptScore W2004082485C41008148 @default.
- W2004082485 hasConceptScore W2004082485C47446073 @default.
- W2004082485 hasConceptScore W2004082485C515207424 @default.
- W2004082485 hasConceptScore W2004082485C55493867 @default.
- W2004082485 hasConceptScore W2004082485C62520636 @default.
- W2004082485 hasConceptScore W2004082485C68709404 @default.
- W2004082485 hasConceptScore W2004082485C86803240 @default.
- W2004082485 hasFunder F4320323573 @default.
- W2004082485 hasIssue "1" @default.
- W2004082485 hasLocation W20040824851 @default.
- W2004082485 hasOpenAccess W2004082485 @default.
- W2004082485 hasPrimaryLocation W20040824851 @default.
- W2004082485 hasRelatedWork W1164537646 @default.
- W2004082485 hasRelatedWork W2024183716 @default.
- W2004082485 hasRelatedWork W2059617446 @default.
- W2004082485 hasRelatedWork W2080203695 @default.
- W2004082485 hasRelatedWork W2080886041 @default.
- W2004082485 hasRelatedWork W2094248253 @default.
- W2004082485 hasRelatedWork W2094262910 @default.
- W2004082485 hasRelatedWork W2583647588 @default.
- W2004082485 hasRelatedWork W2901101993 @default.
- W2004082485 hasRelatedWork W4246894874 @default.
- W2004082485 hasVolume "9" @default.
- W2004082485 isParatext "false" @default.
- W2004082485 isRetracted "false" @default.
- W2004082485 magId "2004082485" @default.
- W2004082485 workType "article" @default.