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• W2004088066 abstract "Previous studies have demonstrated impaired ventricular repolarization in patients with β-TM. However, the effect of iron overload with cardiac<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>T</mml:mtext><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:math>magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiac<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>T</mml:mtext><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:math>MRI in asymptomatic β-TM patients. Twenty-two β-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiac<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>T</mml:mtext><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:math>evaluation. Cardiac<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>T</mml:mtext><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:math>score <20 msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in the β-TM group compared to the healthy controls.<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msub><mml:mi>T</mml:mi><mml:mi>p</mml:mi></mml:msub><mml:mo>−</mml:mo><mml:msub><mml:mi>T</mml:mi><mml:mi>e</mml:mi></mml:msub></mml:mrow></mml:math>and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msub><mml:mi>T</mml:mi><mml:mi>p</mml:mi></mml:msub><mml:mo>−</mml:mo><mml:msub><mml:mi>T</mml:mi><mml:mi>e</mml:mi></mml:msub></mml:mrow></mml:math>dispersions were also significantly prolonged in β-TM group compared to healthy controls.<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mo>(</mml:mo><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub><mml:mo>-</mml:mo><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mi>e</mml:mi></mml:mrow></mml:msub><mml:mo>)</mml:mo><mml:mo>/</mml:mo><mml:mtext>QT</mml:mtext></mml:math>was similar between groups. There was no correlation between repolarization parameters and cardiac<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mtext>T</mml:mtext><mml:msup><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow><mml:mi>*</mml:mi></mml:mrow></mml:msup></mml:math>MRI values. In conclusion, although repolarization parameters were prolonged in asymptomatic β-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load." @default.
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• W2004088066 date "2012-01-01" @default.
• W2004088066 modified "2023-09-26" @default.
• W2004088066 title "The Association between Myocardial Iron Load and Ventricular Repolarization Parameters in Asymptomatic Beta-Thalassemia Patients" @default.
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• W2004088066 doi "https://doi.org/10.1155/2012/170510" @default.
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