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- W2004096181 abstract "Background In eukaryotic cells, chromatin results from the association of DNA with nuclear proteins packaged into hierarchies of organization. The DNA packaging into chromatin is generally recognized as a major mechanism by which the access of genomic DNA is restricted. The physical barrier to the underlying DNA is precisely regulated, at least in part, by the post-translational modifications of histones. Two of the most studied modifications are the acetylation and deacetylation of lysine residues in the nucleosome core histones, under the control of histone acetyltransferases and histone deacetylases, respectively. HDACis such as valproic acid (VPA) and trichostatin A (TSA) induce acetylation of histones and non-histone proteins, which is correlated with nucleosome remodeling and transcriptional activation [1]. In some cases the DNA methylation state and presence of chromatin-associated nonhistone proteins are also affected by HDACis [2,3]. Here we investigated by image analysis procedures whether VPA and TSA, in consequence of their epigenetic action, would affect chromatin supraorganization in different cell lines." @default.
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- W2004096181 date "2013-03-01" @default.
- W2004096181 modified "2023-10-10" @default.
- W2004096181 title "Chromatin remodeling induced by histone deacetylase inhibitors (HDACis) in HeLa, NIH 3T3 and HepG2 cells" @default.
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- W2004096181 doi "https://doi.org/10.1186/1756-8935-6-s1-p17" @default.
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