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- W2004100725 abstract "When the highly reactive fluorinating agent, AsF5·ClF3 in ClF3, designated ACFS, was applied to the clipped skin of the rat, a fourth degree burn of nonspecific type was produced. The entire thickness of the skin and part of the underlying musculature were involved. After 2 weeks, normal healing of the burn was well advanced. In the dosage employed, 30–90 mg, the burn produced by ACFS was sufficient to elicit signs of shock. Activity of the animals was reduced and a considerable degree of hemoconcentration occurred. Apart from the burn itself, other pathologic change was almost entirely absent, Histologic evidence of systemic chemical intoxication could not be adduced. The amount of arsenic present in the skin of the burned area decreased with the passage of time following application of the agent. A concomitant increase in blood arsenic concentration was noted, continuing for at least 48 hours. The levels attained exceeded those seen in rats seriously poisoned with arsenite or lewisite. It was found that the arsenic in the blood of ACFS-burned rats was mainly associated with the erythrocytes, specifically with the hemoglobin. Dialysis experiments indicated that this arsenic was relatively firmly bound. Fractionation of the arsenic compounds present in dialyzates of whole blood from ACFS-burned rats revealed that most of the arsenic was in a pentavalent from, although the presence of a small proportion of trivalent compound was demonstrated. In addition to arsenic, fluorine appeared in the blood of rats after the administration of ACFS to the skin. It has been concluded that the most significant sequelae of the ACFS burn are related to effects on the distribution of body fluids and are not referable to the absorption of toxic arsenic and fluorine compounds." @default.
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- W2004100725 date "1962-07-01" @default.
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- W2004100725 title "The action of an arsenic pentafluoride?Chlorine trifluoride complex on rats" @default.
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- W2004100725 doi "https://doi.org/10.1016/0041-008x(62)90037-6" @default.
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