FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004102565> ?p ?o ?g. }

• W2004102565 endingPage "938" @default.
• W2004102565 startingPage "938" @default.
• W2004102565 abstract "This study analyzes additional mechanisms behind the ocular hypotensive effect of prostaglandin F (PGF) receptor (FP receptor) agonists PGF2alpha and fluprostenol (fluprostenol-isopropyl ester [travoprost]), which reduce intraocular pressure (IOP) in patients with glaucoma probably by enhancing uveoscleral flow. The trabecular meshwork (TM) is actively involved in IOP regulation through contractile mechanisms. Contractility of TM is induced by endothelin (ET)-1, a possible pathogenic factor in glaucoma. The involvement of FP receptor agonists in the ET-1 effects on TM function was studied.The effects of FP receptor agonists on contractility of bovine TM (BTM) were investigated using a force-length transducer. The effects of PGF2alpha on intracellular Ca2+ ([Ca2+]i) mobilization in cultured cells were measured using fura-2AM. The expression of the FP receptor protein was examined using Western blot analysis.The ET-1-induced (10(-8) M) contraction in isolated BTM was inhibited by PGF2alpha (10(-6) M) and fluprostenol (10(-6) M). This effect was blocked by FP receptor antagonists. Carbachol-induced contraction or baseline tension was not affected by PGF2alpha or fluprostenol. In cultured TM cells, ET-1 caused a transient increase in [Ca2+]i that was reduced by PGF2alpha. No reduction occurred in the presence of the FP receptor antagonist Al-8810. Western blot analysis revealed the expression of the FP receptor in native and cultured TM.FP receptor agonists operate by direct interaction with ET-1-induced contractility of TM. This effect is mediated by the FP receptor. Thus, FP receptor agonists may decrease IOP by enhancing aqueous humor outflow through the TM by inhibiting ET-1-dependent mechanisms." @default.
• W2004102565 created "2016-06-24" @default.
• W2004102565 creator A5007238581 @default.
• W2004102565 creator A5013602770 @default.
• W2004102565 creator A5062693516 @default.
• W2004102565 creator A5078625560 @default.
• W2004102565 creator A5079455074 @default.
• W2004102565 creator A5081013332 @default.
• W2004102565 creator A5090700813 @default.
• W2004102565 date "2006-03-01" @default.
• W2004102565 modified "2023-10-16" @default.
• W2004102565 title "Endothelin Antagonism: Effects of FP Receptor Agonists Prostaglandin F_2αand Fluprostenol on Trabecular Meshwork Contractility" @default.
• W2004102565 cites W1501759973 @default.
• W2004102565 cites W156469326 @default.
• W2004102565 cites W1585390129 @default.
• W2004102565 cites W1588123829 @default.
• W2004102565 cites W1589820617 @default.
• W2004102565 cites W1594596038 @default.
• W2004102565 cites W1968176401 @default.
• W2004102565 cites W1968302061 @default.
• W2004102565 cites W1970063550 @default.
• W2004102565 cites W1971003043 @default.
• W2004102565 cites W1974287150 @default.
• W2004102565 cites W1976387869 @default.
• W2004102565 cites W1985689227 @default.
• W2004102565 cites W1987641397 @default.
• W2004102565 cites W1997828183 @default.
• W2004102565 cites W1998278484 @default.
• W2004102565 cites W1998521301 @default.
• W2004102565 cites W2001622302 @default.
• W2004102565 cites W2002193991 @default.
• W2004102565 cites W2005218170 @default.
• W2004102565 cites W2030251743 @default.
• W2004102565 cites W2031919819 @default.
• W2004102565 cites W2038407307 @default.
• W2004102565 cites W2039445266 @default.
• W2004102565 cites W2040098583 @default.
• W2004102565 cites W2047430862 @default.
• W2004102565 cites W2051918516 @default.
• W2004102565 cites W2057786121 @default.
• W2004102565 cites W2066899417 @default.
• W2004102565 cites W2071605868 @default.
• W2004102565 cites W2075573512 @default.
• W2004102565 cites W2079202995 @default.
• W2004102565 cites W2103131763 @default.
• W2004102565 cites W2107775650 @default.
• W2004102565 cites W2110039638 @default.
• W2004102565 cites W2128187673 @default.
• W2004102565 cites W2141260882 @default.
• W2004102565 cites W2161294753 @default.
• W2004102565 cites W2167077199 @default.
• W2004102565 cites W2167835345 @default.
• W2004102565 cites W2170476052 @default.
• W2004102565 cites W2297989745 @default.
• W2004102565 cites W2339647786 @default.
• W2004102565 cites W2399938893 @default.
• W2004102565 cites W2408099444 @default.
• W2004102565 cites W2424195283 @default.
• W2004102565 cites W2429612901 @default.
• W2004102565 cites W37884275 @default.
• W2004102565 cites W46501082 @default.
• W2004102565 doi "https://doi.org/10.1167/iovs.05-0527" @default.
• W2004102565 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16505027" @default.
• W2004102565 hasPublicationYear "2006" @default.
• W2004102565 type Work @default.
• W2004102565 sameAs 2004102565 @default.
• W2004102565 citedByCount "49" @default.
• W2004102565 countsByYear W20041025652012 @default.
• W2004102565 countsByYear W20041025652013 @default.
• W2004102565 countsByYear W20041025652014 @default.
• W2004102565 countsByYear W20041025652015 @default.
• W2004102565 countsByYear W20041025652016 @default.
• W2004102565 countsByYear W20041025652017 @default.
• W2004102565 countsByYear W20041025652018 @default.
• W2004102565 countsByYear W20041025652020 @default.
• W2004102565 countsByYear W20041025652021 @default.
• W2004102565 countsByYear W20041025652023 @default.
• W2004102565 crossrefType "journal-article" @default.
• W2004102565 hasAuthorship W2004102565A5007238581 @default.
• W2004102565 hasAuthorship W2004102565A5013602770 @default.
• W2004102565 hasAuthorship W2004102565A5062693516 @default.
• W2004102565 hasAuthorship W2004102565A5078625560 @default.
• W2004102565 hasAuthorship W2004102565A5079455074 @default.
• W2004102565 hasAuthorship W2004102565A5081013332 @default.
• W2004102565 hasAuthorship W2004102565A5090700813 @default.
• W2004102565 hasBestOaLocation W20041025651 @default.
• W2004102565 hasConcept C118487528 @default.
• W2004102565 hasConcept C126322002 @default.
• W2004102565 hasConcept C134018914 @default.
• W2004102565 hasConcept C144980905 @default.
• W2004102565 hasConcept C149601957 @default.
• W2004102565 hasConcept C163415756 @default.
• W2004102565 hasConcept C170493617 @default.
• W2004102565 hasConcept C185592680 @default.
• W2004102565 hasConcept C2776885963 @default.
• W2004102565 hasConcept C2778122271 @default.
• W2004102565 hasConcept C2778938600 @default.
• W2004102565 hasConcept C2778988552 @default.

• next