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- W2004103992 abstract "In utero diethylstilbestrol (DES) exposure results in long term reproductive consequences. Preliminary evidence suggests a link between prenatal DES exposure and long term alterations in the immune system. To further test this hypothesis, we compared the phytohemaglutinin (PHA) and concavlin A (con A) induced blastogenic response of mononuclear cell in prenatally exposed women (n=13) to age matched non DES exposed women (n=9). 15 ml. of whole blood obtained during the early follicular phase of cycling women were heparinized, diluted 1:2, layered over ficoll-paqun density gradient. The mononuclear cells were washed X 3 (10%, R.P.M.I. 1640). Aliquots (final cone, of 5 × 105ml). Either PHA (7.5ug-1ug/ml) or Con-A were added to each well. After 48 hours of incubation at 37° C the cells were pulsed with 1 Cμ-thymidine(H-Td), reincubated for 18 hours, harvested, counted, and a geometric mean of 3 determinations obtained. Results: Decreasing H-Td proliferation responses paralleled declining mitogen concentrations both with PHA and Con-A. Con-A showed no significantly different response in cells from DES subjects compared to controls. In contrast, PHA responses were greater in DES subjects (p<.005 2 way ANOVA). These data indicate long lasting effects on the immune system in DES exposed women. Such lasting effects on the immune system may be accounted for by a genomic mechanism altering the cellular responses in daughter cells throughout the reproductive years." @default.
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- W2004103992 date "1993-05-01" @default.
- W2004103992 modified "2023-09-27" @default.
- W2004103992 title "ALTERED MONONUCLEAR CELL IMMUNE RESPONSE IN WOMEN EXPOSED TO DES IN UTERO" @default.
- W2004103992 doi "https://doi.org/10.1203/00006450-199305001-00403" @default.
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