FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004104085> ?p ?o ?g. }

• W2004104085 endingPage "278" @default.
• W2004104085 startingPage "274" @default.
• W2004104085 abstract "Kielmeyera coriacea Mart. (Clusiaceae), known as “Pau Santo”, is used to treat several tropical diseases. The hydroethanolic extract (HE) of Kielmeyera coriacea stems and its semi-pure dichloromethane constituent (DCM) produced an anti-immobility effect in rats submitted to the forced swimming test (FST), suggesting a antidepressant-like profile. This study evaluated the effect of intra-median raphe nucleus (MRN) microinjection of 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone, present in large quantity in the HE from Kielmeyera coriacea stems, on immobility behaviour in the FST in rats. The effects of xanthone were compared with intra-MRN microinjections of Way100635 (5-HT1A antagonist) or (+) 8-OH-DPAT (5-HT1A agonist). Locomotor activity in the open-field test (OFT) was evaluated as a complementary measure. Xanthone (0.3 ng) or Way100635 (2.5 μg) reduced, whereas (+) 8-OH-DPAT (5.0 μg) increased immobility time in the FST. Way100635 (2.5 or 5.0 μg) completely reversed the effects of (+) 8-OHDPAT (5.0 μg), and potentiated the anti-immobility effect of the ineffective dose of xanthone (0.2 ng) in the FST. The association of effective doses of (+) 8-OH-DPAT (5.0 μg) and xanthone (0.3 ng) annulled the effect of each compound on immobility time. These results suggest that xanthone acts as an antagonist at 5-HT1A autoreceptors in MRN and increases serotonin (5-HT) availability in projection regions, proving to be a prototype drug that may be useful in mood isorders such as depression, or indeed be a beneficial adjunctive treatment improving the efficacy and/or accelerating the effects of antidepressant drugs in patients with major depression." @default.
• W2004104085 created "2016-06-24" @default.
• W2004104085 creator A5046983337 @default.
• W2004104085 creator A5051139254 @default.
• W2004104085 creator A5054974337 @default.
• W2004104085 creator A5065479909 @default.
• W2004104085 creator A5078943152 @default.
• W2004104085 creator A5081691148 @default.
• W2004104085 creator A5082492989 @default.
• W2004104085 date "2010-03-01" @default.
• W2004104085 modified "2023-10-18" @default.
• W2004104085 title "Effect of xanthone from Kielmeyera coriacea stems on serotonergic neurons of the median raphe nucleus" @default.
• W2004104085 cites W1928086561 @default.
• W2004104085 cites W1963690073 @default.
• W2004104085 cites W1966685725 @default.
• W2004104085 cites W1969615734 @default.
• W2004104085 cites W1973386992 @default.
• W2004104085 cites W1991133531 @default.
• W2004104085 cites W1994857533 @default.
• W2004104085 cites W1998088135 @default.
• W2004104085 cites W2004131847 @default.
• W2004104085 cites W2007046516 @default.
• W2004104085 cites W2020590429 @default.
• W2004104085 cites W2029003010 @default.
• W2004104085 cites W2041849031 @default.
• W2004104085 cites W2042198171 @default.
• W2004104085 cites W2056237366 @default.
• W2004104085 cites W2069284379 @default.
• W2004104085 cites W2070290419 @default.
• W2004104085 cites W2073291801 @default.
• W2004104085 cites W2075752735 @default.
• W2004104085 cites W2092377028 @default.
• W2004104085 cites W2094924193 @default.
• W2004104085 cites W2101868083 @default.
• W2004104085 cites W2113765770 @default.
• W2004104085 cites W2135729576 @default.
• W2004104085 cites W2181113067 @default.
• W2004104085 doi "https://doi.org/10.1016/j.phymed.2009.07.002" @default.
• W2004104085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19674881" @default.
• W2004104085 hasPublicationYear "2010" @default.
• W2004104085 type Work @default.
• W2004104085 sameAs 2004104085 @default.
• W2004104085 citedByCount "20" @default.
• W2004104085 countsByYear W20041040852012 @default.
• W2004104085 countsByYear W20041040852013 @default.
• W2004104085 countsByYear W20041040852014 @default.
• W2004104085 countsByYear W20041040852015 @default.
• W2004104085 countsByYear W20041040852016 @default.
• W2004104085 countsByYear W20041040852018 @default.
• W2004104085 countsByYear W20041040852019 @default.
• W2004104085 countsByYear W20041040852021 @default.
• W2004104085 countsByYear W20041040852022 @default.
• W2004104085 crossrefType "journal-article" @default.
• W2004104085 hasAuthorship W2004104085A5046983337 @default.
• W2004104085 hasAuthorship W2004104085A5051139254 @default.
• W2004104085 hasAuthorship W2004104085A5054974337 @default.
• W2004104085 hasAuthorship W2004104085A5065479909 @default.
• W2004104085 hasAuthorship W2004104085A5078943152 @default.
• W2004104085 hasAuthorship W2004104085A5081691148 @default.
• W2004104085 hasAuthorship W2004104085A5082492989 @default.
• W2004104085 hasBestOaLocation W20041040851 @default.
• W2004104085 hasConcept C126322002 @default.
• W2004104085 hasConcept C136569192 @default.
• W2004104085 hasConcept C170493617 @default.
• W2004104085 hasConcept C185592680 @default.
• W2004104085 hasConcept C2775842281 @default.
• W2004104085 hasConcept C2775864247 @default.
• W2004104085 hasConcept C2776570665 @default.
• W2004104085 hasConcept C2776885963 @default.
• W2004104085 hasConcept C2777865548 @default.
• W2004104085 hasConcept C2779177272 @default.
• W2004104085 hasConcept C2781161787 @default.
• W2004104085 hasConcept C37000724 @default.
• W2004104085 hasConcept C55493867 @default.
• W2004104085 hasConcept C71240020 @default.
• W2004104085 hasConcept C71924100 @default.
• W2004104085 hasConcept C98274493 @default.
• W2004104085 hasConceptScore W2004104085C126322002 @default.
• W2004104085 hasConceptScore W2004104085C136569192 @default.
• W2004104085 hasConceptScore W2004104085C170493617 @default.
• W2004104085 hasConceptScore W2004104085C185592680 @default.
• W2004104085 hasConceptScore W2004104085C2775842281 @default.
• W2004104085 hasConceptScore W2004104085C2775864247 @default.
• W2004104085 hasConceptScore W2004104085C2776570665 @default.
• W2004104085 hasConceptScore W2004104085C2776885963 @default.
• W2004104085 hasConceptScore W2004104085C2777865548 @default.
• W2004104085 hasConceptScore W2004104085C2779177272 @default.
• W2004104085 hasConceptScore W2004104085C2781161787 @default.
• W2004104085 hasConceptScore W2004104085C37000724 @default.
• W2004104085 hasConceptScore W2004104085C55493867 @default.
• W2004104085 hasConceptScore W2004104085C71240020 @default.
• W2004104085 hasConceptScore W2004104085C71924100 @default.
• W2004104085 hasConceptScore W2004104085C98274493 @default.
• W2004104085 hasIssue "3-4" @default.
• W2004104085 hasLocation W20041040851 @default.
• W2004104085 hasLocation W20041040852 @default.
• W2004104085 hasOpenAccess W2004104085 @default.
• W2004104085 hasPrimaryLocation W20041040851 @default.

• next