FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004104883> ?p ?o ?g. }

• W2004104883 endingPage "275" @default.
• W2004104883 startingPage "270" @default.
• W2004104883 abstract "Tomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was visualized via synchrotron radiation X-ray computed microtomography during the drug release process. The surface areas and three dimensional parameters of the tablet core were calculated based on the three dimensional reconstruction of the images. At different stages of the drug release process, the surface morphology, the hydration, the swelling, and the structure changing of the tablet, were visualized from the two dimensional monochrome X-ray images. The three dimensional volumes of the remaining tablet core correlated well with the percentages of felodipine (R = 0.9988). Also, the three dimensional surface area almost unchanged during the drug release process, which clearly demonstrated the intrinsic drug release mechanism of the osmotic drug delivery system. In conclusion, the synchrotron radiation X-ray computed microtomography, with rapid acquisition, high intensity and micro-scale spatial resolution, was found to be a useful tool for the quantitative elucidation of the intrinsic drug release kinetics and the three dimensional parameters such as surface areas of the remained core obtained by the synchrotron radiation. Thus, X-ray computed microtomography can be considered as a new and complimentary analytical tool to standard compendial pharmaceutical tests for quality control of osmotic drug delivery systems." @default.
• W2004104883 created "2016-06-24" @default.
• W2004104883 creator A5014815673 @default.
• W2004104883 creator A5026614129 @default.
• W2004104883 creator A5027024676 @default.
• W2004104883 creator A5045979088 @default.
• W2004104883 creator A5058165407 @default.
• W2004104883 creator A5058955044 @default.
• W2004104883 creator A5064710443 @default.
• W2004104883 creator A5068299891 @default.
• W2004104883 creator A5079045106 @default.
• W2004104883 date "2012-05-01" @default.
• W2004104883 modified "2023-09-25" @default.
• W2004104883 title "Microstructural investigation to the controlled release kinetics of monolith osmotic pump tablets via synchrotron radiation X-ray microtomography" @default.
• W2004104883 cites W1965141078 @default.
• W2004104883 cites W1965608975 @default.
• W2004104883 cites W1982424617 @default.
• W2004104883 cites W1987718489 @default.
• W2004104883 cites W1993309629 @default.
• W2004104883 cites W1994310341 @default.
• W2004104883 cites W2014227913 @default.
• W2004104883 cites W2020274048 @default.
• W2004104883 cites W2022066406 @default.
• W2004104883 cites W2023651391 @default.
• W2004104883 cites W2030541285 @default.
• W2004104883 cites W2031104076 @default.
• W2004104883 cites W2044109296 @default.
• W2004104883 cites W2060236861 @default.
• W2004104883 cites W2062374144 @default.
• W2004104883 cites W2062810479 @default.
• W2004104883 cites W2062935859 @default.
• W2004104883 cites W2067320567 @default.
• W2004104883 cites W2074036277 @default.
• W2004104883 cites W2091098807 @default.
• W2004104883 cites W2133485231 @default.
• W2004104883 cites W2133612713 @default.
• W2004104883 cites W2143645235 @default.
• W2004104883 cites W2156195300 @default.
• W2004104883 cites W2189984932 @default.
• W2004104883 doi "https://doi.org/10.1016/j.ijpharm.2012.02.017" @default.
• W2004104883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366382" @default.
• W2004104883 hasPublicationYear "2012" @default.
• W2004104883 type Work @default.
• W2004104883 sameAs 2004104883 @default.
• W2004104883 citedByCount "35" @default.
• W2004104883 countsByYear W20041048832013 @default.
• W2004104883 countsByYear W20041048832014 @default.
• W2004104883 countsByYear W20041048832015 @default.
• W2004104883 countsByYear W20041048832016 @default.
• W2004104883 countsByYear W20041048832017 @default.
• W2004104883 countsByYear W20041048832018 @default.
• W2004104883 countsByYear W20041048832019 @default.
• W2004104883 countsByYear W20041048832020 @default.
• W2004104883 countsByYear W20041048832021 @default.
• W2004104883 countsByYear W20041048832022 @default.
• W2004104883 countsByYear W20041048832023 @default.
• W2004104883 crossrefType "journal-article" @default.
• W2004104883 hasAuthorship W2004104883A5014815673 @default.
• W2004104883 hasAuthorship W2004104883A5026614129 @default.
• W2004104883 hasAuthorship W2004104883A5027024676 @default.
• W2004104883 hasAuthorship W2004104883A5045979088 @default.
• W2004104883 hasAuthorship W2004104883A5058165407 @default.
• W2004104883 hasAuthorship W2004104883A5058955044 @default.
• W2004104883 hasAuthorship W2004104883A5064710443 @default.
• W2004104883 hasAuthorship W2004104883A5068299891 @default.
• W2004104883 hasAuthorship W2004104883A5079045106 @default.
• W2004104883 hasConcept C120665830 @default.
• W2004104883 hasConcept C121332964 @default.
• W2004104883 hasConcept C136229726 @default.
• W2004104883 hasConcept C16332341 @default.
• W2004104883 hasConcept C171250308 @default.
• W2004104883 hasConcept C192562407 @default.
• W2004104883 hasConcept C21368211 @default.
• W2004104883 hasConcept C2777825092 @default.
• W2004104883 hasConcept C2779820397 @default.
• W2004104883 hasConcept C71924100 @default.
• W2004104883 hasConceptScore W2004104883C120665830 @default.
• W2004104883 hasConceptScore W2004104883C121332964 @default.
• W2004104883 hasConceptScore W2004104883C136229726 @default.
• W2004104883 hasConceptScore W2004104883C16332341 @default.
• W2004104883 hasConceptScore W2004104883C171250308 @default.
• W2004104883 hasConceptScore W2004104883C192562407 @default.
• W2004104883 hasConceptScore W2004104883C21368211 @default.
• W2004104883 hasConceptScore W2004104883C2777825092 @default.
• W2004104883 hasConceptScore W2004104883C2779820397 @default.
• W2004104883 hasConceptScore W2004104883C71924100 @default.
• W2004104883 hasIssue "2" @default.
• W2004104883 hasLocation W20041048831 @default.
• W2004104883 hasLocation W20041048832 @default.
• W2004104883 hasOpenAccess W2004104883 @default.
• W2004104883 hasPrimaryLocation W20041048831 @default.
• W2004104883 hasRelatedWork W1999680306 @default.
• W2004104883 hasRelatedWork W2016796650 @default.
• W2004104883 hasRelatedWork W2058220901 @default.
• W2004104883 hasRelatedWork W2058921564 @default.
• W2004104883 hasRelatedWork W2078596948 @default.
• W2004104883 hasRelatedWork W2078717318 @default.
• W2004104883 hasRelatedWork W2085308304 @default.

• next