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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004106345> ?p ?o ?g. }

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• W2004106345 abstract "The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy." @default.
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• W2004106345 date "2013-01-10" @default.
• W2004106345 modified "2023-10-15" @default.
• W2004106345 title "The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels" @default.
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• W2004106345 doi "https://doi.org/10.1371/journal.pone.0053710" @default.
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