FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004106975> ?p ?o ?g. }

• W2004106975 endingPage "447" @default.
• W2004106975 startingPage "432" @default.
• W2004106975 abstract "Background Methadone disposition and pharmacodynamics are highly susceptible to interactions with antiretroviral drugs. Methadone clearance and drug interactions have been attributed to cytochrome P4503A4 (CYP3A4), but actual mechanisms are unknown. Drug interactions can be clinically and mechanistically informative. This investigation assessed effects of the protease inhibitor indinavir on methadone pharmacokinetics and pharmacodynamics, hepatic and intestinal CYP3A4/5 activity (using alfentanil), and intestinal transporter activity (using fexofenadine). Methods Twelve healthy volunteers underwent a sequential crossover. On three consecutive days they received oral alfentanil plus fexofenadine, intravenous alfentanil, and intravenous plus oral (deuterium-labeled) methadone. This was repeated after 2 weeks of indinavir. Plasma and urine analytes were measured by mass spectrometry. Opioid effects were measured by miosis. Results Indinavir significantly inhibited hepatic and first-pass CYP3A activity. Intravenous alfentanil systemic clearance and hepatic extraction were reduced to 40-50% of control, apparent oral clearance to 30% of control, and intestinal extraction decreased by half, indicating 50% and 70% inhibition of hepatic and first-pass CYP3A activity. Indinavir increased fexofenadine area under the plasma concentration-time curve 3-fold, suggesting significant P-glycoprotein inhibition. Indinavir had no significant effects on methadone plasma concentrations, methadone N-demethylation, systemic or apparent oral clearance, renal clearance, hepatic extraction or clearance, or bioavailability. Methadone plasma concentration-effect relationships were unaffected by indinavir. Conclusions Despite significant inhibition of hepatic and intestinal CYP3A activity, indinavir had no effect on methadone N-demethylation and clearance, suggesting little or no role for CYP3A in clinical disposition of single-dose methadone. Inhibition of gastrointestinal transporter activity had no influence of methadone bioavailability." @default.
• W2004106975 created "2016-06-24" @default.
• W2004106975 creator A5012844446 @default.
• W2004106975 creator A5054673996 @default.
• W2004106975 creator A5056069653 @default.
• W2004106975 creator A5068096894 @default.
• W2004106975 creator A5085884774 @default.
• W2004106975 date "2012-02-01" @default.
• W2004106975 modified "2023-10-02" @default.
• W2004106975 title "Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A)" @default.
• W2004106975 cites W1494031902 @default.
• W2004106975 cites W1497037168 @default.
• W2004106975 cites W1497221593 @default.
• W2004106975 cites W1538481625 @default.
• W2004106975 cites W1539825368 @default.
• W2004106975 cites W1555210154 @default.
• W2004106975 cites W157723456 @default.
• W2004106975 cites W1846579908 @default.
• W2004106975 cites W1856418608 @default.
• W2004106975 cites W1877120840 @default.
• W2004106975 cites W1969620637 @default.
• W2004106975 cites W1975908811 @default.
• W2004106975 cites W1979097034 @default.
• W2004106975 cites W1981501482 @default.
• W2004106975 cites W1984744701 @default.
• W2004106975 cites W1985046754 @default.
• W2004106975 cites W1987952101 @default.
• W2004106975 cites W1996104441 @default.
• W2004106975 cites W1997987760 @default.
• W2004106975 cites W2013016657 @default.
• W2004106975 cites W2013071683 @default.
• W2004106975 cites W2013258544 @default.
• W2004106975 cites W2016961226 @default.
• W2004106975 cites W2019939029 @default.
• W2004106975 cites W2021011301 @default.
• W2004106975 cites W2022824877 @default.
• W2004106975 cites W2028989559 @default.
• W2004106975 cites W2032047115 @default.
• W2004106975 cites W2032191165 @default.
• W2004106975 cites W2034150627 @default.
• W2004106975 cites W2034590629 @default.
• W2004106975 cites W2034665713 @default.
• W2004106975 cites W2044441243 @default.
• W2004106975 cites W2051212479 @default.
• W2004106975 cites W2055735784 @default.
• W2004106975 cites W2069002111 @default.
• W2004106975 cites W2069249816 @default.
• W2004106975 cites W2070014315 @default.
• W2004106975 cites W2070866101 @default.
• W2004106975 cites W2078387155 @default.
• W2004106975 cites W2079853768 @default.
• W2004106975 cites W2081577644 @default.
• W2004106975 cites W2081870667 @default.
• W2004106975 cites W2085782819 @default.
• W2004106975 cites W2093023603 @default.
• W2004106975 cites W2094015709 @default.
• W2004106975 cites W2097475597 @default.
• W2004106975 cites W2098187188 @default.
• W2004106975 cites W2109313097 @default.
• W2004106975 cites W2109818488 @default.
• W2004106975 cites W2112634018 @default.
• W2004106975 cites W2115722806 @default.
• W2004106975 cites W2125894790 @default.
• W2004106975 cites W2127867423 @default.
• W2004106975 cites W2127961073 @default.
• W2004106975 cites W2131828698 @default.
• W2004106975 cites W2132303375 @default.
• W2004106975 cites W2133432475 @default.
• W2004106975 cites W2134431157 @default.
• W2004106975 cites W2140057322 @default.
• W2004106975 cites W2140660745 @default.
• W2004106975 cites W2140975778 @default.
• W2004106975 cites W2142306898 @default.
• W2004106975 cites W2142327374 @default.
• W2004106975 cites W2142573506 @default.
• W2004106975 cites W2144815258 @default.
• W2004106975 cites W2156472356 @default.
• W2004106975 cites W2158245905 @default.
• W2004106975 cites W2161526651 @default.
• W2004106975 cites W2164113828 @default.
• W2004106975 cites W2167392727 @default.
• W2004106975 cites W2170967030 @default.
• W2004106975 cites W2170967458 @default.
• W2004106975 cites W2171167058 @default.
• W2004106975 cites W2171172687 @default.
• W2004106975 doi "https://doi.org/10.1097/aln.0b013e3182423478" @default.
• W2004106975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3586934" @default.
• W2004106975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22273859" @default.
• W2004106975 hasPublicationYear "2012" @default.
• W2004106975 type Work @default.
• W2004106975 sameAs 2004106975 @default.
• W2004106975 citedByCount "33" @default.
• W2004106975 countsByYear W20041069752013 @default.
• W2004106975 countsByYear W20041069752014 @default.
• W2004106975 countsByYear W20041069752015 @default.
• W2004106975 countsByYear W20041069752016 @default.
• W2004106975 countsByYear W20041069752017 @default.
• W2004106975 countsByYear W20041069752018 @default.

• next