Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004107588> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2004107588 endingPage "255" @default.
- W2004107588 startingPage "249" @default.
- W2004107588 abstract "Abstract The objective of this study was to evaluate the stability of ceftiofur (1mgmL-1)in aqueous solutions at various pH (1, 3, 5, 7.4 and 10) and temperature (0, 8, 25, 37 and 60°C) conditions. The ionic strength of all these solutions was maintained at 0.5 M. Ceftiofur solutions at pH 5 and 7.4 and in distilled water (pH = 6.8) were tested at all the above temperatures. All other solutions were tested at 60°C. Over a period of 84 h, the stability was evaluated by quantifying ceftiofur and its degradation product, desfuroylceftiofur, in the incubation solutions. HPLC was used to analyse these compounds. At 60°C, the rate of degradation was significantly higher at pH 7.4 compared with pH 1, 3, 5 and distilled water. At both 60°C and 25°C, degradation in pH 10 buffer was rapid, with no detectable ceftiofur levels present at the end of 10 min incubation. Degradation rate constants of ceftiofur were 0.79 ± 0.21, 0.61 ± 0.03, 0.44 ± 0.05, 1.27 ± 0.04 and 0.39 ± 0.01 day-1 at pH 1, 3, 5, 7.4 and in distilled water, respectively. Formation of desfuroylceftiofur was the highest (65%) at pH 10. The rate of degradation increased in all aqueous solutions with an increase in the incubation temperature. At pH 7.4 the degradation rate constants were 0.06 ± 0.01, 0.06 ± 0.01, 0.65 ± 0.17, and 1.27 ± 0.05 day-1 at 0, 8, 25, 37 and 67°C, respectively. The energy of activation for ceftiofur degradation was 25, 42 and 28kcalmol-1 at pH 5, 7.4 and in distilled water, respectively. Desfurylceftiofur formation was the greatest at alkaline pH compared with acidic pH. Ceftiofur degradation accelerated the most at pH 7.4 and was most rapid at pH 10. The results of this study are consistent with rapid clearance of ceftiofur at physiological pH." @default.
- W2004107588 created "2016-06-24" @default.
- W2004107588 creator A5031520819 @default.
- W2004107588 creator A5059534716 @default.
- W2004107588 creator A5061105101 @default.
- W2004107588 date "1999-03-01" @default.
- W2004107588 modified "2023-10-17" @default.
- W2004107588 title "Influence of pH and Temperature on Kinetics of Ceftiofur Degradation in Aqueous Solutions" @default.
- W2004107588 cites W1968487086 @default.
- W2004107588 cites W1970130681 @default.
- W2004107588 cites W2006906528 @default.
- W2004107588 cites W2056465604 @default.
- W2004107588 cites W2095488178 @default.
- W2004107588 cites W2138239501 @default.
- W2004107588 cites W2163429636 @default.
- W2004107588 cites W2297215755 @default.
- W2004107588 doi "https://doi.org/10.1211/0022357991772411" @default.
- W2004107588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10344624" @default.
- W2004107588 hasPublicationYear "1999" @default.
- W2004107588 type Work @default.
- W2004107588 sameAs 2004107588 @default.
- W2004107588 citedByCount "21" @default.
- W2004107588 countsByYear W20041075882013 @default.
- W2004107588 countsByYear W20041075882015 @default.
- W2004107588 countsByYear W20041075882016 @default.
- W2004107588 countsByYear W20041075882017 @default.
- W2004107588 countsByYear W20041075882018 @default.
- W2004107588 countsByYear W20041075882020 @default.
- W2004107588 countsByYear W20041075882021 @default.
- W2004107588 countsByYear W20041075882022 @default.
- W2004107588 crossrefType "journal-article" @default.
- W2004107588 hasAuthorship W2004107588A5031520819 @default.
- W2004107588 hasAuthorship W2004107588A5059534716 @default.
- W2004107588 hasAuthorship W2004107588A5061105101 @default.
- W2004107588 hasBestOaLocation W20041075881 @default.
- W2004107588 hasConcept C121332964 @default.
- W2004107588 hasConcept C13965031 @default.
- W2004107588 hasConcept C148898269 @default.
- W2004107588 hasConcept C178790620 @default.
- W2004107588 hasConcept C184651966 @default.
- W2004107588 hasConcept C185592680 @default.
- W2004107588 hasConcept C187428577 @default.
- W2004107588 hasConcept C25642318 @default.
- W2004107588 hasConcept C2779429693 @default.
- W2004107588 hasConcept C2779679103 @default.
- W2004107588 hasConcept C2780122547 @default.
- W2004107588 hasConcept C41008148 @default.
- W2004107588 hasConcept C43617362 @default.
- W2004107588 hasConcept C501593827 @default.
- W2004107588 hasConcept C55493867 @default.
- W2004107588 hasConcept C62520636 @default.
- W2004107588 hasConcept C64778159 @default.
- W2004107588 hasConcept C76155785 @default.
- W2004107588 hasConcept C93391505 @default.
- W2004107588 hasConceptScore W2004107588C121332964 @default.
- W2004107588 hasConceptScore W2004107588C13965031 @default.
- W2004107588 hasConceptScore W2004107588C148898269 @default.
- W2004107588 hasConceptScore W2004107588C178790620 @default.
- W2004107588 hasConceptScore W2004107588C184651966 @default.
- W2004107588 hasConceptScore W2004107588C185592680 @default.
- W2004107588 hasConceptScore W2004107588C187428577 @default.
- W2004107588 hasConceptScore W2004107588C25642318 @default.
- W2004107588 hasConceptScore W2004107588C2779429693 @default.
- W2004107588 hasConceptScore W2004107588C2779679103 @default.
- W2004107588 hasConceptScore W2004107588C2780122547 @default.
- W2004107588 hasConceptScore W2004107588C41008148 @default.
- W2004107588 hasConceptScore W2004107588C43617362 @default.
- W2004107588 hasConceptScore W2004107588C501593827 @default.
- W2004107588 hasConceptScore W2004107588C55493867 @default.
- W2004107588 hasConceptScore W2004107588C62520636 @default.
- W2004107588 hasConceptScore W2004107588C64778159 @default.
- W2004107588 hasConceptScore W2004107588C76155785 @default.
- W2004107588 hasConceptScore W2004107588C93391505 @default.
- W2004107588 hasIssue "3" @default.
- W2004107588 hasLocation W20041075881 @default.
- W2004107588 hasLocation W20041075882 @default.
- W2004107588 hasOpenAccess W2004107588 @default.
- W2004107588 hasPrimaryLocation W20041075881 @default.
- W2004107588 hasRelatedWork W1970400998 @default.
- W2004107588 hasRelatedWork W1975862620 @default.
- W2004107588 hasRelatedWork W2005541585 @default.
- W2004107588 hasRelatedWork W2081763891 @default.
- W2004107588 hasRelatedWork W2151837456 @default.
- W2004107588 hasRelatedWork W2159953747 @default.
- W2004107588 hasRelatedWork W3028250401 @default.
- W2004107588 hasRelatedWork W3166324380 @default.
- W2004107588 hasRelatedWork W4320003560 @default.
- W2004107588 hasRelatedWork W4375817442 @default.
- W2004107588 hasVolume "51" @default.
- W2004107588 isParatext "false" @default.
- W2004107588 isRetracted "false" @default.
- W2004107588 magId "2004107588" @default.
- W2004107588 workType "article" @default.