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- W2004111877 abstract "We previously reported that some systemic lupus erythematosus (SLE) patients have a population of circulating memory B cells with > 2-fold higher levels of CD19. We show here that the presence of CD19hi B cells correlates with long-term adverse outcomes. These B cells do not appear anergic, as they exhibit high basal levels of phosphorylated Syk and ERK1/2, signal transduce in response to BCR crosslinking, and can become plasma cells (PCs) in vitro. Autoreactive anti-Smith (Sm) B cells are enriched in this population and the degree of enrichment correlates with the log of the serum anti-Sm titer, arguing that they undergo clonal expansion before PC differentiation. PC differentiation may occur at sites of inflammation, as CD19hi B cells have elevated CXCR3 levels and chemotax in response to its ligand CXCL9. Thus, CD19hi B cells are precursors to anti-self PCs, and identify an SLE patient subset likely to experience poor clinical outcomes." @default.
- W2004111877 created "2016-06-24" @default.
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- W2004111877 date "2008-02-01" @default.
- W2004111877 modified "2023-09-27" @default.
- W2004111877 title "A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE" @default.
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- W2004111877 doi "https://doi.org/10.1016/j.clim.2007.10.004" @default.
- W2004111877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2812414" @default.
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