FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004112159> ?p ?o ?g. }

• W2004112159 abstract "Introduction: Donor site seromas are common complications following Latissimus dorsi breast reconstructions (LDBR), as shown in the UK National Mastectomy and Breast Reconstruction audit. Level I clinical evidence following the performance of an RCT supports ‘fixation’ of the back skin flaps by quilting sutures 1 . Fibrin sealants (Tisseel) have been postulated to reduce seromas after simple mastectomy and axillary dissections 2 , but their role in reducing donor site seromas after breast reconstruction has yet to be performed in a ‘robust’ clinical trial. The aim of this RCT was to compare Tisseel against Control (no Tisseel) on the incidence of seromas after LDBR. Methods: In an ethics approved single centre, single-blinded study comprising 2 surgeons from 2005–2010; 106 women were randomised to either Control (52) or Tisseel (54) interventions after immediate or delayed breast reconstructions. Sixteen patient9s were excluded as follows due to incomplete data at 3 months or re-operations of the donor site for complications. The types of breast reconstructions comprised implant-assisted LD (LDI) in 45 women, 23 extended LD flaps (ELD) and 23 ELD with implant (ELDI). Immediate breast reconstructions (n=87) comprised the majority compared to only 4 delayed procedures. Intraoperative drains were placed to the breast, axilla and donor site (x two) as per standard practice. A 0.5% fibrinogen concentration was used in a hydraulic hand-held Tisseel spray application to the donor site chest wall over 60 seconds. Two stay sutures were pre-placed 2 cm adjacent to the donor wound skin edges above and below prior to the Tisseel application. In the control group, 2 drains only were placed. The primary outcome measure was the total seroma volumes from all the sites over 3 months. This was used for the power calculation of the sample size and showed a requirement for a minimum of 95 women. Secondary outcomes included the volumes of the donor site seromas, and the frequency of post-drain removal donor site aspirations of all symptomatic seromas by patient self-report. Results: The effect of Tisseel glue was to reduce the mean total drain (breast, axilla and back) volume from 2170ml to 1919ml (P=0.05, Mann-Whitney) within 7–10 days. The donor site seroma volumes were similar between the 2 groups over 3 months. The mean donor site total drain volumes (LD donor site drain volume and symptomatic donor site aspirations) were 5412ml in the Control group (840-6252), compared to the Tisseel group producing 4646ml (5384-738). There were no statistical differences between the frequencies or volumes of patient reported seromas aspirated post-drain removal between the two groups. This comprised a mean of 4 aspirations (range 0–13) in the Control group compared to a mean of 9 aspirations (range 0–11) after the use of Tisseel (P=0.548). Conclusion: Tisseel glue may reduce the ‘early’ effect of seroma development, but has not shown any significant role in minimising the potential ‘shearing’ of the donor site skin flaps causing later seroma formation. Current evidence recommends quilting sutures as the gold-standard in reducing this complication. 1. Daltrey I et. al. BJS 2006; 93(7):825–830. 2. Jain PK et. al. BJS 2004; 91:54–60. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-16-07." @default.
• W2004112159 created "2016-06-24" @default.
• W2004112159 creator A5008579427 @default.
• W2004112159 creator A5026296714 @default.
• W2004112159 creator A5049273272 @default.
• W2004112159 creator A5068244420 @default.
• W2004112159 creator A5076292011 @default.
• W2004112159 creator A5080444722 @default.
• W2004112159 date "2011-12-15" @default.
• W2004112159 modified "2023-09-26" @default.
• W2004112159 title "P2-16-07: A Randomised Controlled Trial To Evaluate the Role of Tisseel, a Fibrin Sealant on Seroma Formation in Latissimus dorsi Breast Reconstruction." @default.
• W2004112159 doi "https://doi.org/10.1158/0008-5472.sabcs11-p2-16-07" @default.
• W2004112159 hasPublicationYear "2011" @default.
• W2004112159 type Work @default.
• W2004112159 sameAs 2004112159 @default.
• W2004112159 citedByCount "0" @default.
• W2004112159 crossrefType "proceedings-article" @default.
• W2004112159 hasAuthorship W2004112159A5008579427 @default.
• W2004112159 hasAuthorship W2004112159A5026296714 @default.
• W2004112159 hasAuthorship W2004112159A5049273272 @default.
• W2004112159 hasAuthorship W2004112159A5068244420 @default.
• W2004112159 hasAuthorship W2004112159A5076292011 @default.
• W2004112159 hasAuthorship W2004112159A5080444722 @default.
• W2004112159 hasConcept C121608353 @default.
• W2004112159 hasConcept C126322002 @default.
• W2004112159 hasConcept C141071460 @default.
• W2004112159 hasConcept C203014093 @default.
• W2004112159 hasConcept C2777757722 @default.
• W2004112159 hasConcept C2779409168 @default.
• W2004112159 hasConcept C2781001896 @default.
• W2004112159 hasConcept C2781037480 @default.
• W2004112159 hasConcept C2781411149 @default.
• W2004112159 hasConcept C530470458 @default.
• W2004112159 hasConcept C54173615 @default.
• W2004112159 hasConcept C71924100 @default.
• W2004112159 hasConcept C81182388 @default.
• W2004112159 hasConceptScore W2004112159C121608353 @default.
• W2004112159 hasConceptScore W2004112159C126322002 @default.
• W2004112159 hasConceptScore W2004112159C141071460 @default.
• W2004112159 hasConceptScore W2004112159C203014093 @default.
• W2004112159 hasConceptScore W2004112159C2777757722 @default.
• W2004112159 hasConceptScore W2004112159C2779409168 @default.
• W2004112159 hasConceptScore W2004112159C2781001896 @default.
• W2004112159 hasConceptScore W2004112159C2781037480 @default.
• W2004112159 hasConceptScore W2004112159C2781411149 @default.
• W2004112159 hasConceptScore W2004112159C530470458 @default.
• W2004112159 hasConceptScore W2004112159C54173615 @default.
• W2004112159 hasConceptScore W2004112159C71924100 @default.
• W2004112159 hasConceptScore W2004112159C81182388 @default.
• W2004112159 hasLocation W20041121591 @default.
• W2004112159 hasOpenAccess W2004112159 @default.
• W2004112159 hasPrimaryLocation W20041121591 @default.
• W2004112159 hasRelatedWork W1580190556 @default.
• W2004112159 hasRelatedWork W1975836749 @default.
• W2004112159 hasRelatedWork W2001975726 @default.
• W2004112159 hasRelatedWork W2037975810 @default.
• W2004112159 hasRelatedWork W2062233656 @default.
• W2004112159 hasRelatedWork W2084053565 @default.
• W2004112159 hasRelatedWork W2159509576 @default.
• W2004112159 hasRelatedWork W2185235222 @default.
• W2004112159 hasRelatedWork W2325880762 @default.
• W2004112159 hasRelatedWork W2397764967 @default.
• W2004112159 hasRelatedWork W2582377426 @default.
• W2004112159 hasRelatedWork W2597612182 @default.
• W2004112159 hasRelatedWork W2739454585 @default.
• W2004112159 hasRelatedWork W2944716197 @default.
• W2004112159 hasRelatedWork W3036023299 @default.
• W2004112159 hasRelatedWork W3043447267 @default.
• W2004112159 hasRelatedWork W3113948561 @default.
• W2004112159 hasRelatedWork W3122953667 @default.
• W2004112159 hasRelatedWork W3205215409 @default.
• W2004112159 hasRelatedWork W3091303571 @default.
• W2004112159 isParatext "false" @default.
• W2004112159 isRetracted "false" @default.
• W2004112159 magId "2004112159" @default.
• W2004112159 workType "article" @default.