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- W2004114761 abstract "Abstract The (2‐phenyl‐2‐trimethylsilyl)ethyl‐(PTMSEL) linker represents a novel fluoride‐sensitive anchor for the solid‐phase synthesis of protected peptides and glycopeptides. Its cleavage is achieved under almost neutral conditions using tetrabutylammonium fluoride trihydrate in dichloromethane thus allowing the construction of complex molecules sensitive to basic and acidic media commonly required for the cleavage of standard linker systems. The advantages of the PTMSEL linker are demonstrated in the synthesis of glycopeptides from the liver intestine (LI)‐cadherin and the mucin MUC1, bearing carbohydrate moieties such as N‐linked chitobiose or O‐linked sialyl‐T N ‐residues. The synthesis of these types of glycopeptides is difficult because they are prone to secondary structure formation during the synthesis on the solid phase as well as in the completely deprotected form. Using the PTMSEL linker these molecules are accessible by automated synthesis according to the Fmoc strategy without frequently observed side reactions such as aspartimide or diketopiperazine formation." @default.
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- W2004114761 date "2003-12-11" @default.
- W2004114761 modified "2023-10-17" @default.
- W2004114761 title "The (2-Phenyl-2-trimethylsilyl)ethyl-(PTMSEL)-Linker in the Synthesis of Glycopeptide Partial Structures of Complex Cell Surface Glycoproteins" @default.
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- W2004114761 doi "https://doi.org/10.1002/chem.200305304" @default.
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