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• W2004125969 abstract "alpha-Sialosyl cholesterol (alpha-SC) that elicited morphological differentiation of rat astrocytes not only lowered intracellular cyclic AMP (cAMP) levels but also inhibited cAMP production induced by either alpha-isoproterenol, cholera toxin, or forskolin. The targets of alpha-SC in the cAMP production system of rat astrocytes were investigated to understand the mechanism of the alpha-SC action on cAMP production. cAMP production evoked by alpha-isoproterenol (1 microM) was entirely canceled by beta blockers such as propranolol and timolol (1 microM), but not by alpha-SC. Concentrations of alpha-SC greater than 15 microM were required for 50% inhibition of the activation by a beta agonist. Although alpha-SC inhibited in a dose-dependent manner the activities of membrane-associated adenylate cyclase that had been stimulated by either GTP gamma S of forskolin, alpha-SC inhibited neither GTP-binding activities nor GTPase activities of the membrane-associated G proteins. These findings suggest that alpha-SC suppresses adenylate cyclase directly, but not beta receptors or G proteins, and that it promotes the morphological differentiation of rat astrocytes through a mechanism regulating directly the cytoskeletal organization, regardless of intracellular cAMP level. alpha-SC (30 microM) suppressed 40% of DNA synthesis in the cell-free system, which contained the cytosolic extracts and the nucleus fraction prepared from rat astrocytoma C6 cells. Approximately 25% of alpha-SC incorporated in the astrocyte cytoplasm was transferred to the nuclei by 10 min after the addition.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
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• W2004125969 date "1993-07-01" @default.
• W2004125969 modified "2023-09-25" @default.
• W2004125969 title "Mechanisms of ?-Sialosyl Cholesterol Action to Suppress Both Cyclic AMP Production and DNA Synthesis of Rat Glial Cells" @default.
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• W2004125969 doi "https://doi.org/10.1111/j.1471-4159.1993.tb03539.x" @default.
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