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- W2004126169 abstract "The TP53 family member TP63 encodes two main isoforms TAp63 and ΔNp63 with distinct, often opposite functions during development and in the adult. ΔNp63 is crucial for the formation of the ectodermal derivatives and epidermis, while TAp63 is essential for heart development. In the adult, ΔNp63 behaves as a cell survival factor, controlling cell proliferation, adhesion and cell differentiation. In contrast, TAp63 is a proapoptotic factor that protects oocytes from genotoxic insults and prevents premature aging of dermal stem cells. In agreement with these activities, TAp63 is often lost and ΔNp63 overexpressed in cancer cells. Because of their opposite and competitive effects, p63 isoforms could be viewed as Janus two faces. The review focuses on the accumulating data on the p63 functions and regulation in the last decade." @default.
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- W2004126169 date "2012-04-01" @default.
- W2004126169 modified "2023-10-13" @default.
- W2004126169 title "Les deux visages de p63, Janus de la famille p53" @default.
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- W2004126169 doi "https://doi.org/10.1051/medsci/2012284015" @default.
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