Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004129665> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2004129665 endingPage "169" @default.
- W2004129665 startingPage "164" @default.
- W2004129665 abstract "Whether cardiotonic agents can improve the ability of patients with chronic heart failure to exercise remains unknown. Accordingly, the circulatory and respiratory response of 11 patients with severe heart failure refractory to digitalis, diuretic drugs and vasodilators was assessed during upright treadmill exercise before, within 24 hours and after 4 weeks of therapy with amrinone. The purpose of this study was to determine the ability of amrinone therapy to improve exercise hemodynamics, effort tolerance and aerobic capacity of these patients. Acute intravenous administration of amrinone (1.8 ± 0.1 mg/kg body weight) produced the following changes (mean values ± standard error of the mean) in hemodynamic variables during supine rest; increased cardiac index (from 2.04 ± 0.39 to 2.99 ± 0.38 liters/min per m2; p <0.01) and reduced pulmonary wedge pressure (from 24 ± 6 to 14 ± 6 mm Hg; p <0.01) without altering heart rate or mean arterial pressure. Within 24 hours after administration of amrinone, wedge pressure decreased at the onset of (from 25 ± 7 to 14 ± 7 mm Hg) and throughout exercise (p <0.01), whereas the exercise response of cardiac output, arteriovenous oxygen difference, heart rate, pulmonary and systemic vascular resistances, maximal oxygen uptake and the pattern of ventilation remained similar to control values. However, after 4 weeks of amrinone therapy, exercise and aerobic capacities were increased 44 and 48 percent (p <0.03), respectively, whereas the ventilatory response was unchanged. Thus, amrinone is a potent cardiotonic agent that acutely improves the function of the failing heart at rest and during exercise; the maximal aerobic capacity was increased after 4 weeks of therapy. Amrinone therefore appears to hold promise for the management of patients with chronic heart failure." @default.
- W2004129665 created "2016-06-24" @default.
- W2004129665 creator A5003003886 @default.
- W2004129665 creator A5022482703 @default.
- W2004129665 creator A5054937974 @default.
- W2004129665 creator A5062981450 @default.
- W2004129665 creator A5071787815 @default.
- W2004129665 date "1981-07-01" @default.
- W2004129665 modified "2023-09-27" @default.
- W2004129665 title "Amrinone and exercise performance in patients with chronic heart failure" @default.
- W2004129665 cites W1997551743 @default.
- W2004129665 cites W1998336477 @default.
- W2004129665 cites W2000502468 @default.
- W2004129665 cites W2015271042 @default.
- W2004129665 cites W2017380495 @default.
- W2004129665 cites W2025826302 @default.
- W2004129665 cites W2027938050 @default.
- W2004129665 cites W2033296625 @default.
- W2004129665 cites W2036733675 @default.
- W2004129665 cites W2051283584 @default.
- W2004129665 cites W2075238739 @default.
- W2004129665 cites W2079045333 @default.
- W2004129665 cites W2095110868 @default.
- W2004129665 cites W2122268048 @default.
- W2004129665 cites W2157419729 @default.
- W2004129665 cites W2336602334 @default.
- W2004129665 cites W2339667916 @default.
- W2004129665 cites W2883805808 @default.
- W2004129665 doi "https://doi.org/10.1016/0002-9149(81)90586-5" @default.
- W2004129665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7246438" @default.
- W2004129665 hasPublicationYear "1981" @default.
- W2004129665 type Work @default.
- W2004129665 sameAs 2004129665 @default.
- W2004129665 citedByCount "98" @default.
- W2004129665 countsByYear W20041296652012 @default.
- W2004129665 countsByYear W20041296652014 @default.
- W2004129665 countsByYear W20041296652015 @default.
- W2004129665 countsByYear W20041296652016 @default.
- W2004129665 countsByYear W20041296652019 @default.
- W2004129665 crossrefType "journal-article" @default.
- W2004129665 hasAuthorship W2004129665A5003003886 @default.
- W2004129665 hasAuthorship W2004129665A5022482703 @default.
- W2004129665 hasAuthorship W2004129665A5054937974 @default.
- W2004129665 hasAuthorship W2004129665A5062981450 @default.
- W2004129665 hasAuthorship W2004129665A5071787815 @default.
- W2004129665 hasConcept C126322002 @default.
- W2004129665 hasConcept C139940330 @default.
- W2004129665 hasConcept C146556889 @default.
- W2004129665 hasConcept C164705383 @default.
- W2004129665 hasConcept C178853913 @default.
- W2004129665 hasConcept C2777953023 @default.
- W2004129665 hasConcept C2778198053 @default.
- W2004129665 hasConcept C2779739782 @default.
- W2004129665 hasConcept C2779918671 @default.
- W2004129665 hasConcept C2780685332 @default.
- W2004129665 hasConcept C31861589 @default.
- W2004129665 hasConcept C42219234 @default.
- W2004129665 hasConcept C58245268 @default.
- W2004129665 hasConcept C71924100 @default.
- W2004129665 hasConcept C80461066 @default.
- W2004129665 hasConcept C84393581 @default.
- W2004129665 hasConceptScore W2004129665C126322002 @default.
- W2004129665 hasConceptScore W2004129665C139940330 @default.
- W2004129665 hasConceptScore W2004129665C146556889 @default.
- W2004129665 hasConceptScore W2004129665C164705383 @default.
- W2004129665 hasConceptScore W2004129665C178853913 @default.
- W2004129665 hasConceptScore W2004129665C2777953023 @default.
- W2004129665 hasConceptScore W2004129665C2778198053 @default.
- W2004129665 hasConceptScore W2004129665C2779739782 @default.
- W2004129665 hasConceptScore W2004129665C2779918671 @default.
- W2004129665 hasConceptScore W2004129665C2780685332 @default.
- W2004129665 hasConceptScore W2004129665C31861589 @default.
- W2004129665 hasConceptScore W2004129665C42219234 @default.
- W2004129665 hasConceptScore W2004129665C58245268 @default.
- W2004129665 hasConceptScore W2004129665C71924100 @default.
- W2004129665 hasConceptScore W2004129665C80461066 @default.
- W2004129665 hasConceptScore W2004129665C84393581 @default.
- W2004129665 hasIssue "1" @default.
- W2004129665 hasLocation W20041296651 @default.
- W2004129665 hasLocation W20041296652 @default.
- W2004129665 hasOpenAccess W2004129665 @default.
- W2004129665 hasPrimaryLocation W20041296651 @default.
- W2004129665 hasRelatedWork W1975355016 @default.
- W2004129665 hasRelatedWork W1978138049 @default.
- W2004129665 hasRelatedWork W2010738716 @default.
- W2004129665 hasRelatedWork W2010983775 @default.
- W2004129665 hasRelatedWork W2025123971 @default.
- W2004129665 hasRelatedWork W2037023788 @default.
- W2004129665 hasRelatedWork W2043752640 @default.
- W2004129665 hasRelatedWork W2348887841 @default.
- W2004129665 hasRelatedWork W2418546587 @default.
- W2004129665 hasRelatedWork W2427693459 @default.
- W2004129665 hasVolume "48" @default.
- W2004129665 isParatext "false" @default.
- W2004129665 isRetracted "false" @default.
- W2004129665 magId "2004129665" @default.
- W2004129665 workType "article" @default.