FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004133600> ?p ?o ?g. }

• W2004133600 endingPage "e96" @default.
• W2004133600 startingPage "e87" @default.
• W2004133600 abstract "Cartilage oligomeric matrix protein (COMP) is a prominent non-collagenous component of the extracellular matrix (ECM) in articular cartilage. The regulation of COMP synthesis and secretion is critical for the understanding of cartilage homeostasis in health and disease. We therefore investigated the role of bone morphogenetic protein/transforming growth factor-β (BMP/TGFβ) superfamily members on COMP. Articular chondrocytes were isolated from three distinct zones (surface, middle and deep) and cultured as monolayers in serum-free chemically defined medium. Protein levels of COMP were determined in the medium by enzyme-linked immunosorbent assay. The mRNA expression was determined by quantitative real-time reverse-transcription polymerase chain reaction (RT–PCR). TGFβ1 significantly stimulated the expression of COMP at the mRNA and protein levels in the superficial zone in a time-dependent manner. An unexpected discovery was that surface chondrocytes were more responsive to TGFβ isoforms than those in the deep layer. However, BMP-7 and growth differentiation factor-5 (GDF-5) also upregulate COMP expression; the effects were not as potent as those of TGFβ1. Activins A, B and AB demonstrated no effects on COMP in any of the zones. In conclusion, COMP synthesis is differentially regulated by TGFβ1 in the surface and middle zones of bovine articular cartilage. Copyright © 2011 John Wiley & Sons, Ltd." @default.
• W2004133600 created "2016-06-24" @default.
• W2004133600 creator A5021377995 @default.
• W2004133600 creator A5051479554 @default.
• W2004133600 creator A5075777692 @default.
• W2004133600 date "2011-01-14" @default.
• W2004133600 modified "2023-10-11" @default.
• W2004133600 title "Differential response of cartilage oligomeric matrix protein (COMP) to morphogens of bone morphogenetic protein/transforming growth factor-β family in the surface, middle and deep zones of articular cartilage" @default.
• W2004133600 cites W1550768646 @default.
• W2004133600 cites W1605960013 @default.
• W2004133600 cites W1655444266 @default.
• W2004133600 cites W1812743645 @default.
• W2004133600 cites W1910940147 @default.
• W2004133600 cites W1967777610 @default.
• W2004133600 cites W1971345463 @default.
• W2004133600 cites W1974944864 @default.
• W2004133600 cites W1981857301 @default.
• W2004133600 cites W1985392836 @default.
• W2004133600 cites W1986442052 @default.
• W2004133600 cites W1988999184 @default.
• W2004133600 cites W2005259839 @default.
• W2004133600 cites W2008081396 @default.
• W2004133600 cites W2017992936 @default.
• W2004133600 cites W2030483855 @default.
• W2004133600 cites W2031439609 @default.
• W2004133600 cites W2037174353 @default.
• W2004133600 cites W2046080398 @default.
• W2004133600 cites W2057839193 @default.
• W2004133600 cites W2059844441 @default.
• W2004133600 cites W2064909611 @default.
• W2004133600 cites W2075698606 @default.
• W2004133600 cites W2082483686 @default.
• W2004133600 cites W2092156139 @default.
• W2004133600 cites W2097451795 @default.
• W2004133600 cites W2107277218 @default.
• W2004133600 cites W2108170811 @default.
• W2004133600 cites W2110643834 @default.
• W2004133600 cites W2114713835 @default.
• W2004133600 cites W2137855685 @default.
• W2004133600 cites W2154983834 @default.
• W2004133600 cites W2157962408 @default.
• W2004133600 cites W2158691006 @default.
• W2004133600 cites W2160102342 @default.
• W2004133600 cites W2160275878 @default.
• W2004133600 cites W2164893191 @default.
• W2004133600 cites W4323237124 @default.
• W2004133600 doi "https://doi.org/10.1002/term.358" @default.
• W2004133600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21604381" @default.
• W2004133600 hasPublicationYear "2011" @default.
• W2004133600 type Work @default.
• W2004133600 sameAs 2004133600 @default.
• W2004133600 citedByCount "18" @default.
• W2004133600 countsByYear W20041336002013 @default.
• W2004133600 countsByYear W20041336002014 @default.
• W2004133600 countsByYear W20041336002015 @default.
• W2004133600 countsByYear W20041336002016 @default.
• W2004133600 countsByYear W20041336002017 @default.
• W2004133600 countsByYear W20041336002019 @default.
• W2004133600 countsByYear W20041336002020 @default.
• W2004133600 countsByYear W20041336002021 @default.
• W2004133600 countsByYear W20041336002022 @default.
• W2004133600 crossrefType "journal-article" @default.
• W2004133600 hasAuthorship W2004133600A5021377995 @default.
• W2004133600 hasAuthorship W2004133600A5051479554 @default.
• W2004133600 hasAuthorship W2004133600A5075777692 @default.
• W2004133600 hasBestOaLocation W20041336001 @default.
• W2004133600 hasConcept C104317684 @default.
• W2004133600 hasConcept C105702510 @default.
• W2004133600 hasConcept C106487976 @default.
• W2004133600 hasConcept C118131993 @default.
• W2004133600 hasConcept C142724271 @default.
• W2004133600 hasConcept C170493617 @default.
• W2004133600 hasConcept C185592680 @default.
• W2004133600 hasConcept C189165786 @default.
• W2004133600 hasConcept C202751555 @default.
• W2004133600 hasConcept C204787440 @default.
• W2004133600 hasConcept C2775960820 @default.
• W2004133600 hasConcept C2776164576 @default.
• W2004133600 hasConcept C2778232976 @default.
• W2004133600 hasConcept C2780550940 @default.
• W2004133600 hasConcept C30352789 @default.
• W2004133600 hasConcept C31507581 @default.
• W2004133600 hasConcept C43617362 @default.
• W2004133600 hasConcept C55493867 @default.
• W2004133600 hasConcept C71924100 @default.
• W2004133600 hasConcept C86803240 @default.
• W2004133600 hasConcept C95444343 @default.
• W2004133600 hasConceptScore W2004133600C104317684 @default.
• W2004133600 hasConceptScore W2004133600C105702510 @default.
• W2004133600 hasConceptScore W2004133600C106487976 @default.
• W2004133600 hasConceptScore W2004133600C118131993 @default.
• W2004133600 hasConceptScore W2004133600C142724271 @default.
• W2004133600 hasConceptScore W2004133600C170493617 @default.
• W2004133600 hasConceptScore W2004133600C185592680 @default.
• W2004133600 hasConceptScore W2004133600C189165786 @default.
• W2004133600 hasConceptScore W2004133600C202751555 @default.
• W2004133600 hasConceptScore W2004133600C204787440 @default.
• W2004133600 hasConceptScore W2004133600C2775960820 @default.

• next