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• W2004134367 endingPage "382" @default.
• W2004134367 startingPage "370" @default.
• W2004134367 abstract "Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity. The significance of DUBs to the nervous system is underscored by links to various neurological diseases. Owing to cell type or substrate specificity, certain DUBs might also represent therapeutic targets for neurodegeneration. Here, we review recent findings that have shaped our current understanding of emerging functions for DUBs in the nervous system. Many pathways important to the nervous system are regulated by the post-translational conjugation of ubiquitin to target proteins. The reversal of ubiquitination, or deubiquitination, is equally critical to neuronal function. By countering protein ubiquitination, deubiquitinating enzymes (DUBs) help control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity. The significance of DUBs to the nervous system is underscored by links to various neurological diseases. Owing to cell type or substrate specificity, certain DUBs might also represent therapeutic targets for neurodegeneration. Here, we review recent findings that have shaped our current understanding of emerging functions for DUBs in the nervous system. gross lack of coordination. A neurological symptom that usually indicates a dysfunction of neural pathways involved in motor coordination. a family of cysteine and metallo-proteases that cleave chemical bonds between ubiquitin molecules or between ubiquitin and another protein. ubiquitin–ubiquitin linkages that generally target substrate proteins for degradation by the proteasome. ubiquitin-ubiquitin linkages that generally target proteins in non-degradative pathways. ubiquitin conjugation that involves a single moiety of ubiquitin. This type of ubiquitination can alter the sub-cellular localization of a protein and regulate cellular processes such as receptor trafficking and gene transcription. ubiquitin conjugation that involves chains of >1 ubiquitin moiety. A variety of different types of ubiquitin chains are known (e.g. K6, K11, K27, K29, K33, K48 and K63-linked ubiquitin chains). a large molecular complex found in all eukaryotic cells, the proteasome selectively degrades poly-ubiquitinated proteins. It consists of the 20S particle, which proteolyses proteins and one or two regulatory 19S particles. a small regulatory protein that alters the interaction properties of proteins to which it is conjugated." @default.
• W2004134367 created "2016-06-24" @default.
• W2004134367 creator A5015909717 @default.
• W2004134367 creator A5055180300 @default.
• W2004134367 date "2011-07-01" @default.
• W2004134367 modified "2023-10-18" @default.
• W2004134367 title "Balancing act: deubiquitinating enzymes in the nervous system" @default.
• W2004134367 cites W1511827873 @default.
• W2004134367 cites W1545031391 @default.
• W2004134367 cites W1618846043 @default.
• W2004134367 cites W1968055671 @default.
• W2004134367 cites W1971145588 @default.
• W2004134367 cites W1972436933 @default.
• W2004134367 cites W1972548761 @default.
• W2004134367 cites W1977733856 @default.
• W2004134367 cites W1977860801 @default.
• W2004134367 cites W1987700535 @default.
• W2004134367 cites W1991258715 @default.
• W2004134367 cites W1991931975 @default.
• W2004134367 cites W1992341804 @default.
• W2004134367 cites W1992436832 @default.
• W2004134367 cites W1995392239 @default.
• W2004134367 cites W1997673335 @default.
• W2004134367 cites W2000063663 @default.
• W2004134367 cites W2002156115 @default.
• W2004134367 cites W2004879226 @default.
• W2004134367 cites W2005572424 @default.
• W2004134367 cites W2008793606 @default.
• W2004134367 cites W2009092091 @default.
• W2004134367 cites W2010515885 @default.
• W2004134367 cites W2011369317 @default.
• W2004134367 cites W2012296420 @default.
• W2004134367 cites W2013339424 @default.
• W2004134367 cites W2016236499 @default.
• W2004134367 cites W2017794722 @default.
• W2004134367 cites W2018228226 @default.
• W2004134367 cites W2018263680 @default.
• W2004134367 cites W2020053069 @default.
• W2004134367 cites W2023053159 @default.
• W2004134367 cites W2023475421 @default.
• W2004134367 cites W2024205301 @default.
• W2004134367 cites W2026263038 @default.
• W2004134367 cites W2027832797 @default.
• W2004134367 cites W2029262926 @default.
• W2004134367 cites W2031663826 @default.
• W2004134367 cites W2032459218 @default.
• W2004134367 cites W2034537895 @default.
• W2004134367 cites W2036468298 @default.
• W2004134367 cites W2041577842 @default.
• W2004134367 cites W2042811939 @default.
• W2004134367 cites W2044305470 @default.
• W2004134367 cites W2044867241 @default.
• W2004134367 cites W2050551000 @default.
• W2004134367 cites W2051094352 @default.
• W2004134367 cites W2051939475 @default.
• W2004134367 cites W2058209707 @default.
• W2004134367 cites W2060222742 @default.
• W2004134367 cites W2068621468 @default.
• W2004134367 cites W2068802700 @default.
• W2004134367 cites W2069537999 @default.
• W2004134367 cites W2073012734 @default.
• W2004134367 cites W2078072437 @default.
• W2004134367 cites W2078507150 @default.
• W2004134367 cites W2081631520 @default.
• W2004134367 cites W2087541840 @default.
• W2004134367 cites W2088660706 @default.
• W2004134367 cites W2088724822 @default.
• W2004134367 cites W2090054185 @default.
• W2004134367 cites W2094903254 @default.
• W2004134367 cites W2095351891 @default.
• W2004134367 cites W2097978324 @default.
• W2004134367 cites W2100423216 @default.
• W2004134367 cites W2102075074 @default.
• W2004134367 cites W2102645070 @default.
• W2004134367 cites W2106969933 @default.
• W2004134367 cites W2110360858 @default.
• W2004134367 cites W2113019206 @default.
• W2004134367 cites W2117641259 @default.
• W2004134367 cites W2118225942 @default.
• W2004134367 cites W2119271253 @default.
• W2004134367 cites W2119415370 @default.
• W2004134367 cites W2120611983 @default.
• W2004134367 cites W2120947942 @default.
• W2004134367 cites W2121615969 @default.
• W2004134367 cites W2122077427 @default.
• W2004134367 cites W2125733108 @default.
• W2004134367 cites W2128573741 @default.
• W2004134367 cites W2129183209 @default.
• W2004134367 cites W2131041787 @default.
• W2004134367 cites W2136412949 @default.
• W2004134367 cites W2137827020 @default.
• W2004134367 cites W2138247439 @default.
• W2004134367 cites W2139364069 @default.
• W2004134367 cites W2139886899 @default.
• W2004134367 cites W2141402394 @default.
• W2004134367 cites W2144279829 @default.
• W2004134367 cites W2147065485 @default.
• W2004134367 cites W2152351845 @default.

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