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• W2004134439 abstract "Summary. The efficacy of two different daily doses of itraconazole (ITRA) and the combination of flucytosine (5‐FC) with ITRA in the treatment of an experimental model of cryptococcosis in hamsters was studied. Five groups of 20 animals each were inoculated by the intracardiac route with 10 5 cells of Cryptococcus neoformans . Treatment started 3 days after the infection, and was administered by gavage for 30 days. ITRA was applied at a daily dose of 25 mg kg ‐1 or 50 mg kg ‐1 and the combination of 5‐FC and ITRA was given at 75 mg kg ‐1 day ‐1 or 50 mg kg ‐1 day ‐1 respectively. One group of 20 hamsters received the vehicle and was used as a control group. Treatment evaluation was based on the following parameters: number of surviving animals 60 days after the infection; presence of encapsulated yeasts on microscopic examination of wet preparations of brain, lungs, liver, spleen and kidneys at necropsy; and brain qualitative (massive seeding) and quantitative cultures (determination of colony forming units, CFU). ITRA 50 (50 mg kg day ‐1 ) was the most effective treatment according to the studied parameters; 70% of brain cultures became negative and 95% of the treated hamsters survived to the end of the study period. ITRA efficacy was dose dependent. The combination of ITRA with 5‐FC was less effective than administering the drugs separately; the reason for this finding is not known. The results obtained in this study should encourage the use of high doses of ITRA in cases of disseminated cryptococcosis in humans. Zusammenfassung. In einem Tiermodell mit Cryptococcose an Hamstern wurde die Wirksamkeit von Itraconazol in zwei unterschiedlichen Dosierungen (25 mg kg ‐1 d ‐1 ) bzw. 50 mg kg ‐1 d ‐1 ) und die der Kombination von Flucytosin (75 mg kg ‐1 d ‐1 ) + Itraconazol (50 mg kg ‐1 d ‐1 ) untersucht. Die Studie wurde an fünt Gruppen zu je 20 Tieren durchgeführt. die intrakardial mit 10 5 Cryptococcus neoformans ‐Zellen infiziert worden waren. Eine Gruppe von 20 Hamstern erhielt nur das Lösungsmittel und diente als Therapiekontrolle. Die Auswertung der antimykotischen Behandlung stützte sich auf folgende Parameter: Zahl der überlebenden Tiere 60 d nach Infektion; mikroskopischer Nachweis bekapselter Hefen in Naßpräparaten aus Nekropsiematerial von Gehirn, Lunge, Leber, Milz und Nieren; kultureller Nachweis von Cr. neoformans aus Gehirn‐Homogenat qualitativ und quantitativ. Itraconazol 50 mg kg ‐1 d ‐1 erwies sich als das wirksamste Behandlungsverfahren: es führte zu 70% Negativität der Gehirnkulturen und 95%überlebenden Tieren. Die Itraconazol‐Wirksamkeit war dosisabhängig. Die Kombination von Itraconazol mit Flucytosin war weniger wirksam als beide Wirkstoffe für sich allein, für diesen Befund gibt es keine Erklärung. Die Ergebnisse ermuntern den Einsatz von Itraconazol in hohen Dosen bei der disseminierten Cryptococcose des Menschen." @default.
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• W2004134439 date "1995-11-01" @default.
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• W2004134439 title "Itraconazole and flucytosine+itraconazole combination in the treatment of experimental cryptococcosis in hamsters" @default.
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• W2004134439 doi "https://doi.org/10.1111/j.1439-0507.1995.tb00018.x" @default.
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