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• W2004134510 abstract "A method is described of measuring the K + ‐evoked release of endogenous 5‐hydroxytryptamine (5‐HT) and noradrenaline (NA) from slices prepared from rat cortex. There was no difference in either the spontaneous (basal) or K + ‐evoked release of 5‐HT or NA from cortical slices prepared from handled animals and those given a single electroconvulsive shock (ECS) either 30 min or 24 h earlier. In chronic studies, rats were either handled or given an ECS 5 times over 10 days and cortical slices prepared. There was no difference in 5‐HT or NA release between the groups 30 min after the last treatment other than a modest attentuation of spontaneous NA release following ECS treatment. However 24 h after the last treatment K + ‐evoked release (above basal release) of 5‐HT and NA was inhibited by 84% and 48%, respectively. These data demonstrate that following a single ECS, normal 5‐HT and NA release is seen at a time when GABA release is markedly inhibited. After repeated ECS the release of both monoamines was markedly inhibited. These 5‐HT changes may be involved in the enhanced 5‐HT‐receptor function seen after repeated ECS." @default.
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• W2004134510 date "1987-09-01" @default.
• W2004134510 modified "2023-10-18" @default.
• W2004134510 title "The effects of single and repeated electroconvulsive shock administration on the release of 5-hydroxytryptamine and noradrenaline from cortical slices of rat brain" @default.
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• W2004134510 doi "https://doi.org/10.1111/j.1476-5381.1987.tb11291.x" @default.
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