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- W2004134685 abstract "Abstract Recent studies showed that organophosphorus pesticides can increase incidence of metabolic disorders and diabetes. Considering the importance of pancreas in regulating blood glucose, the effect of malathion on essential elements of glucose-stimulated insulin secretion (GSIS) in in vitro and in vivo conditions were evaluated. After dividing of rats into control and treatment groups, oral glucose tolerance test (OGTT) was examined and then kinetic of glucose as well as pancreatic response to raise blood glucose were evaluated. After isolation of islets from pancreas, its function as well as oxidative stress markers and essential elements of GSIS were examined. Malathion at dose of 400 mg/kg impaired GTT and increased AUC0–180 min (P = 0.047) and T1/2β of glucose (P = 0.0016), and reduced insulin response (P = 0.005) 30 min after oral administering of glucose. In addition to impaired glucose tolerance, there were significant increases in lipid peroxidation (P Conclusion Dysfunction of glucose metabolism and impairment of insulin secretion are associated with a depletion of energy and induction of oxidative stress following acute exposure to malathion." @default.
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- W2004134685 date "2013-05-01" @default.
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- W2004134685 title "On the biochemical and molecular mechanisms by which malathion induces dysfunction in pancreatic islets in vivo and in vitro" @default.
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- W2004134685 doi "https://doi.org/10.1016/j.pestbp.2013.04.003" @default.
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