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- W2004135059 abstract "Hypoxia can cause not only acute kidney injury but also chronic kidney diseases. Hypoxia-inducible transcription factors activated by hypoxia play an important role in the cellular and tissular adaptation to low oxygen conditions. Hypoxia-inducible transcription factor-1 is composed of alpha and beta subunits. Hypoxia-inducible transcription factor-1alpha (HIF-1alpha) is known as a key regulator in protective role of renal damage by induction of downstream protective genes such as erythropoietin, heme oxygenase-1, vascular endothelial growth factor and glucose transporter-1. These proteins coded by protective genes are sufficient to induce renoprotection. So we hypothesize that recombinant adeno-associated viral HIF-1alpha gene will offer potential as a novel means to treat renal disease and can ameliorate renal damage efficiently by the injection of renal vein." @default.
- W2004135059 created "2016-06-24" @default.
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- W2004135059 date "2008-01-01" @default.
- W2004135059 modified "2023-10-14" @default.
- W2004135059 title "Induction of renoprotective gene expression by hypoxia-inducible transcription factor-1α ameliorates renal damage" @default.
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- W2004135059 doi "https://doi.org/10.1016/j.mehy.2007.08.029" @default.
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