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- W2004135086 abstract "We present a new model of the three-dimensional structure of chromosomes. With DNA and protein staining it could be shown by high-resolution scanning electron microscopy that metaphase chromosomes are mainly composed of DNA packed in “chromomeres” (coiled solenoides) and a dynamic matrix formed of parallel protein fibers. In the centromeric region, the chromomeres are less densly packed, giving insight into the matrix fibers. We postulate that chromosome condensation is achieved by the binding of solenoids to matrix fibers which have contact sites to one another and move antiparallel to each other. As condensation progresses, loops of solenoids accumulate to form additional chromomeres, causing chromosomes to become successively shorter and thicker as more chromomeres are formed. For sterical reasons, a tension vertical to the axial direction forces the chromatids apart. The model can simply explain the enormous variety of chromosome morphology in plant and animal systems by varying only a few cytological parameters. Primary and secondary constrictions and deletions are defined as regions devoid of chromomeres. Even in the highly condensed metaphase, all genes would be easily accessible." @default.
- W2004135086 created "2016-06-24" @default.
- W2004135086 creator A5040083768 @default.
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- W2004135086 date "2000-11-01" @default.
- W2004135086 modified "2023-10-16" @default.
- W2004135086 title "A New Chromosome Model" @default.
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- W2004135086 doi "https://doi.org/10.1006/jsbi.2000.4310" @default.
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