Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004138424> ?p ?o ?g. }
- W2004138424 endingPage "617" @default.
- W2004138424 startingPage "605" @default.
- W2004138424 abstract "Carvedilol used in cardiovascular diseases has systemic bioavailability of 25–35%. The objective of this study was production of lectin-modified poly(ethylene-co-vinyl acetate) (PEVA) as mucoadhesive nanoparticles to enhance low oral bioavailability of carvedilol. Nanoparticles were prepared by the emulsification-solvent evaporation method using a two-level factorial design. The studied variables included the vinyl acetate content of the polymer, drug and polymer content. Surface modification of PEVA nanoparticles with lectin was carried out by the adsorption method and coupling efficiency was determined using the Bradford assay. Mucoadhesion of nanoparticles was studied on mucin. The particle size, polydispersity index, zeta potential, drug loading and drug release from nanoparticles were studied. The morphology of nanoparticles and crystalline status of the entrapped drug were studied by SEM, DSC and XRD tests, respectively. Results showed the most effective factor on particle size and zeta potential was the interaction of polymer and drug content while, drug loading efficiency and mucoadhesion were more affected by the interaction of polymer type and drug content. Drug concentration was the most effective variable on the drug release rate. The drug was in amorphous state in nanoparticles. The optimum nanoparticles obtained by 45 mg of copolymer contained 12% vinyl acetate/4.3 ml of organic phase and drug concentration of 37.5 wt% of polymer." @default.
- W2004138424 created "2016-06-24" @default.
- W2004138424 creator A5027690668 @default.
- W2004138424 creator A5065779854 @default.
- W2004138424 date "2013-08-13" @default.
- W2004138424 modified "2023-09-27" @default.
- W2004138424 title "Novel lectin-modified poly(ethylene-co-vinyl acetate) mucoadhesive nanoparticles of carvedilol: preparation and<i>in vitro</i>optimization using a two-level factorial design" @default.
- W2004138424 cites W116002999 @default.
- W2004138424 cites W1553373140 @default.
- W2004138424 cites W1557218829 @default.
- W2004138424 cites W171962313 @default.
- W2004138424 cites W1860060910 @default.
- W2004138424 cites W1970020271 @default.
- W2004138424 cites W1981043096 @default.
- W2004138424 cites W1985019251 @default.
- W2004138424 cites W1994229453 @default.
- W2004138424 cites W2000542157 @default.
- W2004138424 cites W2000911974 @default.
- W2004138424 cites W2001596955 @default.
- W2004138424 cites W2019930410 @default.
- W2004138424 cites W2024511387 @default.
- W2004138424 cites W2034383957 @default.
- W2004138424 cites W2037149037 @default.
- W2004138424 cites W2041885280 @default.
- W2004138424 cites W2046845840 @default.
- W2004138424 cites W2047763238 @default.
- W2004138424 cites W2052480302 @default.
- W2004138424 cites W2052927590 @default.
- W2004138424 cites W2053559208 @default.
- W2004138424 cites W2054189154 @default.
- W2004138424 cites W2055335182 @default.
- W2004138424 cites W2057431839 @default.
- W2004138424 cites W2060218937 @default.
- W2004138424 cites W2076405992 @default.
- W2004138424 cites W2077440292 @default.
- W2004138424 cites W2078534693 @default.
- W2004138424 cites W2082865634 @default.
- W2004138424 cites W2084270646 @default.
- W2004138424 cites W2106241844 @default.
- W2004138424 cites W2112533311 @default.
- W2004138424 cites W2119014197 @default.
- W2004138424 cites W2119138662 @default.
- W2004138424 cites W2127065516 @default.
- W2004138424 cites W2147883214 @default.
- W2004138424 cites W2148940647 @default.
- W2004138424 cites W2153800066 @default.
- W2004138424 cites W2155518779 @default.
- W2004138424 cites W2156285632 @default.
- W2004138424 cites W2158048265 @default.
- W2004138424 cites W2162933728 @default.
- W2004138424 cites W2170422174 @default.
- W2004138424 cites W2320617100 @default.
- W2004138424 cites W2322390626 @default.
- W2004138424 cites W4235065663 @default.
- W2004138424 cites W4293247451 @default.
- W2004138424 doi "https://doi.org/10.3109/10837450.2013.819011" @default.
- W2004138424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23937559" @default.
- W2004138424 hasPublicationYear "2013" @default.
- W2004138424 type Work @default.
- W2004138424 sameAs 2004138424 @default.
- W2004138424 citedByCount "13" @default.
- W2004138424 countsByYear W20041384242014 @default.
- W2004138424 countsByYear W20041384242015 @default.
- W2004138424 countsByYear W20041384242017 @default.
- W2004138424 countsByYear W20041384242018 @default.
- W2004138424 countsByYear W20041384242019 @default.
- W2004138424 countsByYear W20041384242020 @default.
- W2004138424 countsByYear W20041384242021 @default.
- W2004138424 countsByYear W20041384242022 @default.
- W2004138424 countsByYear W20041384242023 @default.
- W2004138424 crossrefType "journal-article" @default.
- W2004138424 hasAuthorship W2004138424A5027690668 @default.
- W2004138424 hasAuthorship W2004138424A5065779854 @default.
- W2004138424 hasConcept C105795698 @default.
- W2004138424 hasConcept C127413603 @default.
- W2004138424 hasConcept C13245373 @default.
- W2004138424 hasConcept C13965031 @default.
- W2004138424 hasConcept C147789679 @default.
- W2004138424 hasConcept C155672457 @default.
- W2004138424 hasConcept C15920480 @default.
- W2004138424 hasConcept C169222746 @default.
- W2004138424 hasConcept C171250308 @default.
- W2004138424 hasConcept C178790620 @default.
- W2004138424 hasConcept C181389837 @default.
- W2004138424 hasConcept C185592680 @default.
- W2004138424 hasConcept C187530423 @default.
- W2004138424 hasConcept C192562407 @default.
- W2004138424 hasConcept C2779820397 @default.
- W2004138424 hasConcept C2780020223 @default.
- W2004138424 hasConcept C2780165375 @default.
- W2004138424 hasConcept C2780762185 @default.
- W2004138424 hasConcept C33923547 @default.
- W2004138424 hasConcept C42360764 @default.
- W2004138424 hasConcept C43617362 @default.
- W2004138424 hasConcept C521977710 @default.
- W2004138424 hasConcept C71924100 @default.
- W2004138424 hasConcept C86181022 @default.
- W2004138424 hasConcept C98274493 @default.