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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004142272> ?p ?o ?g. }

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• W2004142272 abstract "In order to identify a high-affinity, selective antagonist for the A2B subtype adenosine receptor, more than 40 1,8-disubstituted-3-(3-methoxypropyl) xanthines were prepared and evaluated for their binding affinity at recombinant human adenosine receptors, mainly of the A2A and A2B subtypes. Some of the 1-ethyl-3-(3-methoxypropyl)-8-aryl substituted derivatives 15(a–m) showed moderate-to-high affinity at human A2B receptors, with compound 15d showing A2B selectivity over the other A receptors assayed (A1, A2A, A3) of 34-fold or over." @default.
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• W2004142272 date "2009-05-01" @default.
• W2004142272 modified "2023-09-27" @default.
• W2004142272 title "Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A2B receptor antagonists" @default.
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• W2004142272 doi "https://doi.org/10.1016/j.bmc.2009.03.029" @default.
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