FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004142277> ?p ?o ?g. }

• W2004142277 endingPage "6319" @default.
• W2004142277 startingPage "6309" @default.
• W2004142277 abstract "Although β-dicarbonyl compounds are regularly employed as Michael donors, intermediates arising from the Michael addition of unsaturated β-ketoesters to α,β-unsaturated aldehydes are susceptible to multiple subsequent reaction pathways. We designed cyclic unsaturated β-ketoester substrates that enabled the development of the first diphenyl prolinol silyl ether catalyzed Michael–Michael cascade reaction initiated by a β-dicarbonyl Michael donor to form cyclohexene products. The reaction conditions we developed for this Michael–Michael cascade reaction were also amenable to a variety of linear unsaturated β-ketoester substrates, including some of the same linear unsaturated β-ketoester substrates that were previously ineffective in Michael–Michael cascade reactions. These studies thus revealed that a change in simple reaction conditions, such as solvent and additives, enables the same substrate to undergo different cascade reactions, thereby accessing different molecular scaffolds. These studies also culminated in the development of a general organocatalyzed Michael–Michael cascade reaction that generates highly functionalized cyclohexenes with up to four stereocenters, in up to 97% yield, 32:1 dr, and 99% ee, in a single step from a variety of unsaturated β-ketoesters." @default.
• W2004142277 created "2016-06-24" @default.
• W2004142277 creator A5056009591 @default.
• W2004142277 creator A5062792184 @default.
• W2004142277 creator A5075963516 @default.
• W2004142277 date "2011-07-08" @default.
• W2004142277 modified "2023-10-16" @default.
• W2004142277 title "A General Organocatalyzed Michael–Michael Cascade Reaction Generates Functionalized Cyclohexenes" @default.
• W2004142277 cites W1964740544 @default.
• W2004142277 cites W1976400387 @default.
• W2004142277 cites W1977799153 @default.
• W2004142277 cites W1982768808 @default.
• W2004142277 cites W1990066689 @default.
• W2004142277 cites W1992256898 @default.
• W2004142277 cites W2001325794 @default.
• W2004142277 cites W2013821889 @default.
• W2004142277 cites W2021918837 @default.
• W2004142277 cites W2032318211 @default.
• W2004142277 cites W2043772748 @default.
• W2004142277 cites W2045810066 @default.
• W2004142277 cites W2052828956 @default.
• W2004142277 cites W2069334149 @default.
• W2004142277 cites W2081069004 @default.
• W2004142277 cites W2084614276 @default.
• W2004142277 cites W2111280484 @default.
• W2004142277 cites W2117602779 @default.
• W2004142277 cites W2132037114 @default.
• W2004142277 cites W2133868402 @default.
• W2004142277 cites W2138091879 @default.
• W2004142277 cites W2138460179 @default.
• W2004142277 cites W2151262204 @default.
• W2004142277 cites W2165450009 @default.
• W2004142277 cites W2171270106 @default.
• W2004142277 cites W2172247375 @default.
• W2004142277 cites W2949414351 @default.
• W2004142277 cites W2949436950 @default.
• W2004142277 cites W2949870823 @default.
• W2004142277 cites W2950152926 @default.
• W2004142277 doi "https://doi.org/10.1021/jo201140a" @default.
• W2004142277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3198797" @default.
• W2004142277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21714480" @default.
• W2004142277 hasPublicationYear "2011" @default.
• W2004142277 type Work @default.
• W2004142277 sameAs 2004142277 @default.
• W2004142277 citedByCount "27" @default.
• W2004142277 countsByYear W20041422772012 @default.
• W2004142277 countsByYear W20041422772013 @default.
• W2004142277 countsByYear W20041422772014 @default.
• W2004142277 countsByYear W20041422772016 @default.
• W2004142277 countsByYear W20041422772017 @default.
• W2004142277 countsByYear W20041422772019 @default.
• W2004142277 countsByYear W20041422772020 @default.
• W2004142277 countsByYear W20041422772021 @default.
• W2004142277 crossrefType "journal-article" @default.
• W2004142277 hasAuthorship W2004142277A5056009591 @default.
• W2004142277 hasAuthorship W2004142277A5062792184 @default.
• W2004142277 hasAuthorship W2004142277A5075963516 @default.
• W2004142277 hasBestOaLocation W20041422772 @default.
• W2004142277 hasConcept C112423150 @default.
• W2004142277 hasConcept C134195300 @default.
• W2004142277 hasConcept C146686406 @default.
• W2004142277 hasConcept C161790260 @default.
• W2004142277 hasConcept C178790620 @default.
• W2004142277 hasConcept C185592680 @default.
• W2004142277 hasConcept C21951064 @default.
• W2004142277 hasConcept C2779484182 @default.
• W2004142277 hasConcept C2780741609 @default.
• W2004142277 hasConcept C34146451 @default.
• W2004142277 hasConcept C43617362 @default.
• W2004142277 hasConcept C5304478 @default.
• W2004142277 hasConcept C58548122 @default.
• W2004142277 hasConcept C66972969 @default.
• W2004142277 hasConcept C92832382 @default.
• W2004142277 hasConceptScore W2004142277C112423150 @default.
• W2004142277 hasConceptScore W2004142277C134195300 @default.
• W2004142277 hasConceptScore W2004142277C146686406 @default.
• W2004142277 hasConceptScore W2004142277C161790260 @default.
• W2004142277 hasConceptScore W2004142277C178790620 @default.
• W2004142277 hasConceptScore W2004142277C185592680 @default.
• W2004142277 hasConceptScore W2004142277C21951064 @default.
• W2004142277 hasConceptScore W2004142277C2779484182 @default.
• W2004142277 hasConceptScore W2004142277C2780741609 @default.
• W2004142277 hasConceptScore W2004142277C34146451 @default.
• W2004142277 hasConceptScore W2004142277C43617362 @default.
• W2004142277 hasConceptScore W2004142277C5304478 @default.
• W2004142277 hasConceptScore W2004142277C58548122 @default.
• W2004142277 hasConceptScore W2004142277C66972969 @default.
• W2004142277 hasConceptScore W2004142277C92832382 @default.
• W2004142277 hasIssue "15" @default.
• W2004142277 hasLocation W20041422771 @default.
• W2004142277 hasLocation W20041422772 @default.
• W2004142277 hasLocation W20041422773 @default.
• W2004142277 hasLocation W20041422774 @default.
• W2004142277 hasOpenAccess W2004142277 @default.
• W2004142277 hasPrimaryLocation W20041422771 @default.
• W2004142277 hasRelatedWork W1977451448 @default.
• W2004142277 hasRelatedWork W1983534633 @default.
• W2004142277 hasRelatedWork W2004142277 @default.

• next